ID C3JHY3_RHOER Unreviewed; 362 AA.
AC C3JHY3;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Pyruvate dehydrogenase E1 component, alpha subunit {ECO:0000313|EMBL:EEN88834.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:EEN88834.1};
GN Name=pdhA {ECO:0000313|EMBL:EEN88834.1};
GN ORFNames=RHOER0001_0369 {ECO:0000313|EMBL:EEN88834.1};
OS Rhodococcus erythropolis SK121.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus; Rhodococcus erythropolis group.
OX NCBI_TaxID=596309 {ECO:0000313|EMBL:EEN88834.1, ECO:0000313|Proteomes:UP000005836};
RN [1] {ECO:0000313|EMBL:EEN88834.1, ECO:0000313|Proteomes:UP000005836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK121 {ECO:0000313|EMBL:EEN88834.1,
RC ECO:0000313|Proteomes:UP000005836};
RA Sebastian Y., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEN88834.1}.
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DR EMBL; ACNO01000014; EEN88834.1; -; Genomic_DNA.
DR RefSeq; WP_003941309.1; NZ_ACNO01000014.1.
DR AlphaFoldDB; C3JHY3; -.
DR Proteomes; UP000005836; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EEN88834.1}; Pyruvate {ECO:0000313|EMBL:EEN88834.1}.
FT DOMAIN 44..310
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 362 AA; 39214 MW; E5C6AEE2E38DD25E CRC64;
MVDNLDYPVQ LIQPNGARVC RPEFDRLITD IGPDELLSLY RDLVVSRRID TEAVALQRQG
EIGLWAPMLG QEAAQVGSAR ALAPGDFAFT SYREHAVAYC RGVPPELLTT MWRGISHSGW
DPEQFSVTNP AIVVGSQGLH ATGYALGAHL DGAEIATIAY FGDGATSQGD IAEAMGFAAS
FRVGVVFFCQ NNQWAISEPV SLQSRTPISH RAIGYGIPAI RVDGNDVLAV LAVTRSALNR
AREGSGPTFI EAITCRMGPH TTSDDPSRYR TDTDMSEWRS RDPLERMRLL LGRRDLLGEN
ELSTIAAAAD DIAAGLRRAT IALADPPPSA LFDHVYAEAH PLIDAEREEH RAYLGSLEGA
SS
//
