ID C3JI86_RHOER Unreviewed; 750 AA.
AC C3JI86;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=4-hydroxythreonine-4-phosphate dehydrogenase {ECO:0000313|EMBL:EEN88780.1};
DE EC=1.1.1.262 {ECO:0000313|EMBL:EEN88780.1};
GN Name=pdxA {ECO:0000313|EMBL:EEN88780.1};
GN ORFNames=RHOER0001_6784 {ECO:0000313|EMBL:EEN88780.1};
OS Rhodococcus erythropolis SK121.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus; Rhodococcus erythropolis group.
OX NCBI_TaxID=596309 {ECO:0000313|EMBL:EEN88780.1, ECO:0000313|Proteomes:UP000005836};
RN [1] {ECO:0000313|EMBL:EEN88780.1, ECO:0000313|Proteomes:UP000005836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK121 {ECO:0000313|EMBL:EEN88780.1,
RC ECO:0000313|Proteomes:UP000005836};
RA Sebastian Y., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Strausberg R.L., Nelson K.E.;
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the four-carbon acid sugar kinase family.
CC {ECO:0000256|ARBA:ARBA00005715}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEN88780.1}.
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DR EMBL; ACNO01000016; EEN88780.1; -; Genomic_DNA.
DR RefSeq; WP_003941418.1; NZ_ACNO01000016.1.
DR AlphaFoldDB; C3JI86; -.
DR Proteomes; UP000005836; Unassembled WGS sequence.
DR GO; GO:0050570; F:4-hydroxythreonine-4-phosphate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.980.20; Four-carbon acid sugar kinase, nucleotide binding domain; 1.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR Gene3D; 3.40.50.10840; Putative sugar-binding, N-terminal domain; 1.
DR InterPro; IPR010737; 4-carb_acid_sugar_kinase_N.
DR InterPro; IPR037051; 4-carb_acid_sugar_kinase_N_sf.
DR InterPro; IPR031475; NBD_C.
DR InterPro; IPR042213; NBD_C_sf.
DR InterPro; IPR005255; PdxA_fam.
DR NCBIfam; TIGR00557; pdxA; 1.
DR PANTHER; PTHR30004; 4-HYDROXYTHREONINE-4-PHOSPHATE DEHYDROGENASE; 1.
DR PANTHER; PTHR30004:SF6; D-THREONATE 4-PHOSPHATE DEHYDROGENASE; 1.
DR Pfam; PF17042; NBD_C; 1.
DR Pfam; PF04166; PdxA; 1.
DR Pfam; PF07005; SBD_N; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR SUPFAM; SSF142764; YgbK-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EEN88780.1}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..212
FT /note="Four-carbon acid sugar kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07005"
FT DOMAIN 235..380
FT /note="Four-carbon acid sugar kinase nucleotide binding"
FT /evidence="ECO:0000259|Pfam:PF17042"
SQ SEQUENCE 750 AA; 78171 MW; C39F3FED8922D3F8 CRC64;
MKPLVIIADD LSGAAESAAG FLLRSSGISL RLGPGAPDGS GVTVFDLHSR RSDPARASRD
VRSVLQSSDG SEIVKKIDSL LRGNIAAEVG ELSRDGSPVI VAAGLPRQGR TVQDGVVLVD
GVALHSTDLW RAESKPAPRS IAEALGPSAI TSGVSLDDIR SGRLNQVLAS ISEAGSVAIC
DVETDSDLQL IVAAAQEVRG SRLVGTSALA TAVARRRTVQ SPVACPSLRD SRFTLVVVGT
ADASAGDQVA LLRDSGAHHI EVNSAELLAH SVDPLPILNA LDRGNVVVSV SGPVVPAESV
HLVSALADLI AAVDAGFSHD EYPIDLVLTG GETARSVLDR LRIDTLSPIY EIEHGAVLSV
DRTGRYIVTR PGSFGNAHSL FSITKFLAHP TPVAAPDSPP SVTPSDNEVN PMSIYSTPLP
LIAVTMGDGA GVGPEVIVPA LLDGETRKRC RPVVVGDAKR LRLAAGVLGI DVDVVAIEGI
KDAEFIDGRI NVIDLDLLPE DLAWGELSAV AGDAAYQYIR VASELAVRGE VQSICTAPLN
KEALHAAGHI YPGHTELLAH LTGTEEVSMM LSTPKLKVIH VTTHIGLLDA VARIEPGLVE
RTIRRGHEAL VRTGNPSPKI GVCGINPHAG ENGLFGYGEE EQKIIPAVEL LKAEGIDVHG
PLPADTAFFL AGRGDYDLIV AMYHDQGHGP VKVLGIEAGV NITVGLPVIR TSVDHGTAFD
IAGKGIAEAG SMVEALRQAA ELATSTFVSK
//
