ID C3K1D9_PSEFS Unreviewed; 1934 AA.
AC C3K1D9;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Alpha-2-macroglobulin {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=PFLU_6111 {ECO:0000313|EMBL:CAY53715.1};
OS Pseudomonas fluorescens (strain SBW25).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=216595 {ECO:0000313|EMBL:CAY53715.1};
RN [1] {ECO:0000313|EMBL:CAY53715.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SBW25 {ECO:0000313|EMBL:CAY53715.1};
RX PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA Jackson R.W., Preston G.M., Zhang X.X., Moon C.D., Gehrig S.M.,
RA Godfrey S.A., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT "Genomic and genetic analyses of diversity and plant interactions of
RT Pseudomonas fluorescens.";
RL Genome Biol. 10:R51.1-R51.16(2009).
RN [2] {ECO:0000313|EMBL:CAI2800237.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SBW25 {ECO:0000313|EMBL:CAI2800237.1};
RA Fortmann-Grote C.;
RL Submitted (OCT-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; OV986001; CAI2800237.1; -; Genomic_DNA.
DR EMBL; AM181176; CAY53715.1; -; Genomic_DNA.
DR RefSeq; WP_015886638.1; NC_012660.1.
DR PATRIC; fig|216595.4.peg.6235; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_000965_2_0_6; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP001152918; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR Gene3D; 2.60.40.3710; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 54..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1045..1184
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 1249..1338
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT REGION 1821..1863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1834..1851
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1934 AA; 211782 MW; A99DDCDDD3B7EFB0 CRC64;
MFDSFKAISR RIVGALLTVV GAVFGQWHPP VWLRAIGRGL ANLGSKARAY PRQTGAGLLG
LVLLAAAGFY GWHWYSNLPQ PHTASYSLHK PNLTDYTQQT PVVDNLQVRF GESVAPLAAI
GKPVTEGITL KPAVAGTWRW ADDRSLLFVP EKDWPIDAHY TVDLAKKNLL ADGVLLDQYS
TQFSTQPFRA TLAQNELYQD PSNPTLKQLV ATFHFSHPVD EDNLRKRVTV TLGKGLAYRD
AQLPNRPEIT FDEKKLNAYV RSAALATPLE STPVSAKLDD GIKARDGGNA SAAPLVAEVT
VPGRYRLTFT GAEVSFVDNA RGEPEPVLMF SSSSAVADET IAGKVQAWLL PEKAQDDTRP
YNSNDIDDAL LARSTKVNLT HVPSVEPLNT LHAFKFKAPA GRAVYVRVPA NLEAIGGYLA
KNPTASLISM PAYPRTLQFL SDGALLSLNG EKRLGFMARG VPGAHVEIAR LLPNQLQHLV
DQSSGSFARP NFGNEYFDRM VERQSLDIPL SSNDPAKTVY DNVDLSRYLT ANGGRRGIFV
LKLSPQDDPA PRTFEYDRSS TSDLRFIVVT DLGIIAKRSS DGSHDVYVQS IGNGSPVADA
QVDIIGRNGL PVSSGHTDGE GHAHFAKLDE LRREKTPLMY VVTRGNDQSF LPIARQSQQL
DLSRFDVGGL EEDGAIDRLS AYLFTDRGLY RPGETAHLGM IVRSGNWKGA LQGLPVELQI
TDPRGLEVIR QPLKLSASGF ETFDFPSSEV APAGEYTATL QLIGEKQTRT DLGSVNFKVR
DFEPDRMKVS LSLHDTPVQG WIPPDQVVAK VTAMHLFGAP ASGRRVTAKM SLSPTLAAFD
RYPDYRFRLN DALEEASTED LAETTVDDNG QAVLDLNLQR FANSTYRLQV MTQVFEAEGG
RNVAAQSALL VSSAPYLVGV KSQDSLSYVA KDAPRQVQWL AVAPDLTPVA VDGLTSEVVE
HRYVSVLVKQ SNGTYKYESR IKNISQPASP LAMTKEGAKQ TLNTSAPGDF TLQLKDANGN
LLNQIDYSVA GRGNTSRSLE RNAELQLRLD KRSYATGDEI AISIRAPYTG AGLITIERDK
VYTQQWFKAD STNSVQHIRV PAGLEGNAYV NVQFVRDMGS AEVYMSPLSY GVVPFSINLD
ARRMALKVEG PAKIEPGQTL DIKVNADRPG RAVVYAVDEG ILQVARYQTP DPLGFFFQKR
ALEVGTSQIL DLILPEFSRL LSGAAPGGDT EGALANHLNP FKRKHQPPVA WWSGLVDLPA
GETVLHYQVP DSFNGKLHLF AVAVDSDSVG VSEANTEVRG PIVITPNVPA FVAPGDVFNV
SAGVFSNLDA AADVKFEVQT SAGLVVQGDK GNTLSLQPRK EGTAEFKIKV GDTLGSADLR
FIAVLPDGKR IQVAETTSIR PLSEHRVALS LGRFDSASKE LKPTRELFSQ LRDVQLGVAA
SPLVWANGLK HYLDDYGYAC TEQLVSKAMP ALIWGGNAPE AEQAFGSAVR MLRQRQNQAG
GFGLWAANPD VAPYASLYAT DFLIEAKERG LPVPEDLLVR SNAYLTDLAN GPSEGLSELR
NRAYASYLLS RQGILVSGAL SDIRERYESY FKDSWQNDLG AAYLAASYKL LKQDRQADTL
FRKIPWRSLV DKWDSDGLYY DPLVHDAEHL HLLARHFPEL MDDVPTTLLD KLGKRLNEQR
YNSLSAALLL RALDNYGQRA QSDMTLKATA WLGDKQQQLL EMAGQPPRAA VPGNTQKLVM
EKSDGPAAFY MLSEAGFDKG AKLKPINNGL EIIHEYLDLK GEPVSKVAVG DEFLVRLRLR
ATDRDQVQQV AVVDLLPGGV EPVYNLPPEP EAASSEESEG EESEYVEEDS QEEQSWQAPI
GETELSNWQP EYVDVRDDRV VLYGTALRDV GTFVYRVRAT NAGTFNTPPA YAEGMYETTL
QGRGKVGQLE ITKP
//