ID   C3MXY7_SULIM            Unreviewed;       855 AA.
AC   C3MXY7;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=aconitate hydratase {ECO:0000256|ARBA:ARBA00012926};
DE            EC=4.2.1.3 {ECO:0000256|ARBA:ARBA00012926};
GN   OrderedLocusNames=M1425_1131 {ECO:0000313|EMBL:ACP37893.1};
OS   Sulfolobus islandicus (strain M.14.25 / Kamchatka #1).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=427317 {ECO:0000313|EMBL:ACP37893.1, ECO:0000313|Proteomes:UP000001350};
RN   [1] {ECO:0000313|EMBL:ACP37893.1, ECO:0000313|Proteomes:UP000001350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.14.25 / Kamchatka #1 {ECO:0000313|Proteomes:UP000001350};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=citrate = D-threo-isocitrate; Xref=Rhea:RHEA:10336,
CC         ChEBI:CHEBI:15562, ChEBI:CHEBI:16947; EC=4.2.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00023501};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the aconitase/IPM isomerase family.
CC       {ECO:0000256|ARBA:ARBA00007185}.
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DR   EMBL; CP001400; ACP37893.1; -; Genomic_DNA.
DR   RefSeq; WP_012711155.1; NC_012588.1.
DR   AlphaFoldDB; C3MXY7; -.
DR   GeneID; 7795479; -.
DR   KEGG; sia:M1425_1131; -.
DR   HOGENOM; CLU_013476_2_1_2; -.
DR   Proteomes; UP000001350; Chromosome.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01586; AcnA_IRP; 1.
DR   Gene3D; 6.10.190.10; -; 1.
DR   Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR   Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR006249; Aconitase/IRP2.
DR   InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   NCBIfam; TIGR01341; aconitase_1; 1.
DR   PANTHER; PTHR11670; ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER; 1.
DR   PANTHER; PTHR11670:SF54; CYTOPLASMIC ACONITATE HYDRATASE; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
DR   PROSITE; PS00450; ACONITASE_1; 1.
DR   PROSITE; PS01244; ACONITASE_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          62..529
FT                   /note="Aconitase/3-isopropylmalate dehydratase large
FT                   subunit alpha/beta/alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00330"
FT   DOMAIN          663..779
FT                   /note="Aconitase A/isopropylmalate dehydratase small
FT                   subunit swivel"
FT                   /evidence="ECO:0000259|Pfam:PF00694"
SQ   SEQUENCE   855 AA;  95887 MW;  1D36C581B46F9BAB CRC64;
     MPSKFSYKGS EIYYYPLKEL EEKGYKISDL PYSIRILIEN VYRNLDGNKI TEEDLENITK
     WKVGEELAFM PTRVVMQDYT GVPLLVDLAA MREKMIQLKK DPKMINPVVP ADLVIDHSVQ
     VDYYGTVYSL EFNMKKEFER NLERYQFLKW AQGAFRNLRI VPPGKGIIHQ VNLEYLSTVV
     TKAEVKGLLT AFPEVIIGTD SHTTMIEGLG ILGWGVGGLE AEAVLLGEPY YLNVPEVIGV
     RLSGEIQEGV TPTDVVLYIT ELLRKKNVVS KFVEFFGPSL SLLSVPDRAT IANMAPEYGT
     TAAYFPIDDV TVSYLELTNR DGEFVKKYSQ LQDLFYDDSR KIRYTDVVEV NLSKIEPAIA
     GPRNPDERIV LREVKGKLSK EKKKKGKYVE DNAVVLAAIT SCTNTSNPTV MLGAGILAKK
     AVEMGLRVPT YIKTSTAPGS PVVAEYLRET ELLPYLEALG FHLVGFGCTT CIGNAGPLPK
     HVEEDIKENG IETYGVISGN RNFEGRINPL LKGTFLASPI LVVAYALAGR IDIDFYNDPI
     GYDPNGKPVY LRDIWPSLKE IKAYMNMALK PELYKKNSNI FEGNELWNSL KTPQGDVYSW
     DEKSTYIRLP PWYTEEKQEE LDDIVNARIL LLLGDKITTD HISPAGPITP DSPAGLYLKQ
     FGVSDLNTYG ARRGNHEVML RGGFFNPKMK NLLVEKEGGY TVHFPDRRIA SVYEVAMQYK
     KEGVPLVIVA GKQYGSGSSR DWAAKVTKLL GVKAVLAESF ERIHRSNLVA MGVIPIQIQD
     WRSLGIKGDE TINIKGIKDL KPKKELVIEF VKSNGEKITT KGIARIDNNV ELTYVKKGGI
     LNYVLEKFLE NERKS
//