ID C3MYM6_SULIM Unreviewed; 289 AA.
AC C3MYM6;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:ACP38005.1};
DE EC=1.1.1.31 {ECO:0000313|EMBL:ACP38005.1};
GN OrderedLocusNames=M1425_1250 {ECO:0000313|EMBL:ACP38005.1};
OS Sulfolobus islandicus (strain M.14.25 / Kamchatka #1).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=427317 {ECO:0000313|EMBL:ACP38005.1, ECO:0000313|Proteomes:UP000001350};
RN [1] {ECO:0000313|EMBL:ACP38005.1, ECO:0000313|Proteomes:UP000001350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M.14.25 / Kamchatka #1 {ECO:0000313|Proteomes:UP000001350};
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
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DR EMBL; CP001400; ACP38005.1; -; Genomic_DNA.
DR RefSeq; WP_012711258.1; NC_012588.1.
DR AlphaFoldDB; C3MYM6; -.
DR GeneID; 84052858; -.
DR KEGG; sia:M1425_1250; -.
DR HOGENOM; CLU_035117_0_6_2; -.
DR Proteomes; UP000001350; Chromosome.
DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000313|EMBL:ACP38005.1}.
FT DOMAIN 2..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 161..281
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
SQ SEQUENCE 289 AA; 31590 MW; C1CBD41C9780809A CRC64;
MKVGLIGLGI MGYRIGANLA KANKLNVVYD RTQEKAESFV KEYKVNRALN PKELVESSDV
IITMLADDNA VKSIVEPLIP LMKGKILIDM STISPTLSIS LAKRIESNGG TMFDAPVIGT
SIFVEQKKLI VLVGGPKDKF DIVNDIAKET ASSVVYMGPN GMGLYAKLVN NLLLGSYVSA
IAEAYNFGIR AGLDPQQVIN ILTTLSSARS PTTELKAPKL LKEDYSTQFA TKHMRKDLEI
VIKEAQNLKI ITPISSLALQ LYKMTEALGY SEVDFISIVE VFKKLSPKT
//
