ID C3PEW2_CORA7 Unreviewed; 285 AA.
AC C3PEW2;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Oxidoreductase, aldo/keto reductase family {ECO:0000313|EMBL:ACP32366.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:ACP32366.1};
GN OrderedLocusNames=cauri_0769 {ECO:0000313|EMBL:ACP32366.1};
OS Corynebacterium aurimucosum (strain ATCC 700975 / DSM 44827 / CIP 107346 /
OS CN-1) (Corynebacterium nigricans).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=548476 {ECO:0000313|EMBL:ACP32366.1, ECO:0000313|Proteomes:UP000002077};
RN [1] {ECO:0000313|EMBL:ACP32366.1, ECO:0000313|Proteomes:UP000002077}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700975 / DSM 44827 / CIP 107346 / CN-1
RC {ECO:0000313|Proteomes:UP000002077};
RX PubMed=20137072; DOI=10.1186/1471-2164-11-91;
RA Trost E., Gotker S., Schneider J., Schneiker-Bekel S., Szczepanowski R.,
RA Tilker A., Viehoever P., Arnold W., Bekel T., Blom J., Gartemann K.H.,
RA Linke B., Goesmann A., Puhler A., Shukla S.K., Tauch A.;
RT "Complete genome sequence and lifestyle of black-pigmented Corynebacterium
RT aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a
RT vaginal swab of a woman with spontaneous abortion.";
RL BMC Genomics 11:91-91(2010).
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DR EMBL; CP001601; ACP32366.1; -; Genomic_DNA.
DR RefSeq; WP_012714923.1; NZ_ACLH01000016.1.
DR AlphaFoldDB; C3PEW2; -.
DR STRING; 548476.cauri_0769; -.
DR GeneID; 31923395; -.
DR KEGG; car:cauri_0769; -.
DR eggNOG; COG0656; Bacteria.
DR HOGENOM; CLU_023205_0_1_11; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000002077; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19071; AKR_AKR1-5-like; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000313|EMBL:ACP32366.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002077}.
FT DOMAIN 20..266
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 53
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 115
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 82
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 285 AA; 32177 MW; 835C21BB98EC0A7C CRC64;
MEDMSVPQTT FNDDREMPLL GLGTYKMHGE ELVRSVREAI DLGYRHFDTA TLYENEEELG
QALNAAMKAG DVTRDELFIT SKVWHDHHGK DKVGQAFRES LDKLQLDYLD LYLIHWPWPQ
GRLYVETFEE IARMQGMGQI ASIGVANFYE ETLQTLIDET GIVPVLNQVE LHPGFTQPEL
RQFHDSHGIV TEAWSPLARG IILNNPEVMA VAEKHDITAG QAVLAYLLSK GISVIPKSSR
RERLEENFAA AEVELTAEDF AALDALDGKE GFGRMFKDPR EFPGD
//
