ID C3SDE3_ECOLX Unreviewed; 465 AA.
AC C3SDE3;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Flagellar hook-associated protein 2 {ECO:0000256|ARBA:ARBA00016246, ECO:0000256|RuleBase:RU362066};
DE Short=HAP2 {ECO:0000256|RuleBase:RU362066};
DE AltName: Full=Flagellar cap protein {ECO:0000256|RuleBase:RU362066};
GN ORFNames=C9E67_11415 {ECO:0000313|EMBL:QCL47737.1}, ECs2663
GN {ECO:0000313|EMBL:ACI72500.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:ACI72500.1};
RN [1] {ECO:0000313|EMBL:ACI72500.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=86-24 {ECO:0000313|EMBL:ACI72500.1}, 87-14
RC {ECO:0000313|EMBL:ACI72501.1}, and TW14359
RC {ECO:0000313|EMBL:ACI72502.1};
RX PubMed=19439656; DOI=10.1073/pnas.0812949106;
RA Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J.,
RA Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E.,
RA Sawyer S.A., Whittam T.S., Tarr P.I.;
RT "A precise reconstruction of the emergence and constrained radiations of
RT Escherichia coli O157 portrayed by backbone concatenomic analysis.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009).
RN [2] {ECO:0000313|EMBL:QCL47737.1, ECO:0000313|Proteomes:UP000298553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=143 {ECO:0000313|EMBL:QCL47737.1,
RC ECO:0000313|Proteomes:UP000298553};
RA Bono J.L., Arthur T.M.;
RT "WGA of Escherichia coli O157:H7: comparison of multiple isolates.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|RuleBase:RU362066}.
CC -!- FUNCTION: Required for the morphogenesis and for the elongation of the
CC flagellar filament by facilitating polymerization of the flagellin
CC monomers at the tip of growing filament. Forms a capping structure,
CC which prevents flagellin subunits (transported through the central
CC channel of the flagellum) from leaking out without polymerization at
CC the distal end. {ECO:0000256|ARBA:ARBA00025175}.
CC -!- SUBUNIT: Homopentamer. {ECO:0000256|ARBA:ARBA00011255,
CC ECO:0000256|RuleBase:RU362066}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362066}.
CC Bacterial flagellum {ECO:0000256|RuleBase:RU362066}.
CC -!- SIMILARITY: Belongs to the FliD family. {ECO:0000256|ARBA:ARBA00009764,
CC ECO:0000256|RuleBase:RU362066}.
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DR EMBL; EU889908; ACI72500.1; -; Genomic_DNA.
DR EMBL; EU889909; ACI72501.1; -; Genomic_DNA.
DR EMBL; EU889910; ACI72502.1; -; Genomic_DNA.
DR EMBL; CP028607; QCL47737.1; -; Genomic_DNA.
DR RefSeq; WP_000146755.1; NZ_VODI01000025.1.
DR AlphaFoldDB; C3SDE3; -.
DR SMR; C3SDE3; -.
DR PATRIC; fig|562.7073.peg.2905; -.
DR OMA; GGRQQIW; -.
DR Proteomes; UP000298553; Chromosome.
DR GO; GO:0009421; C:bacterial-type flagellum filament cap; IEA:InterPro.
DR GO; GO:0009424; C:bacterial-type flagellum hook; IEA:UniProtKB-UniRule.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR InterPro; IPR040026; FliD.
DR InterPro; IPR010809; FliD_C.
DR InterPro; IPR003481; FliD_N.
DR PANTHER; PTHR30288; FLAGELLAR CAP/ASSEMBLY PROTEIN FLID; 1.
DR PANTHER; PTHR30288:SF0; FLAGELLAR HOOK-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF07195; FliD_C; 1.
DR Pfam; PF02465; FliD_N; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum {ECO:0000256|ARBA:ARBA00023143,
KW ECO:0000256|RuleBase:RU362066};
KW Cell projection {ECO:0000313|EMBL:ACI72500.1};
KW Cilium {ECO:0000313|EMBL:ACI72500.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Flagellum {ECO:0000313|EMBL:ACI72500.1};
KW Secreted {ECO:0000256|RuleBase:RU362066}.
FT DOMAIN 11..103
FT /note="Flagellar hook-associated protein 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02465"
FT DOMAIN 219..449
FT /note="Flagellar hook-associated protein 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07195"
SQ SEQUENCE 465 AA; 48153 MW; 1B286643E6483851 CRC64;
MASISSLGVG SGLDLSSILD SLTAAQKATL TPISNQQSSF TAKLSAYGTL KSALTTFQTA
NTALSKADLF SATSSTTAFS ATTAGNAIAG KYTISVTHLA QAQTLTTRTT RDDTKTAIAT
SDSKLTIQQG GDKDPITIDI SAANSSLSGI RDAINNAKAG VSASIINVGN GDYRLSVTSN
DTGLDNAMTL SVSGDDALQS FMGYDASASS NGMEVSVAAQ NAQLTVNNVA IENSSNTISD
ALENITLNLN DVTTGNQTLT ITQDTSKAQT AIKDWVNAYN SLIDTFSSLT KYTAVDAGAD
SQSSSNGALL GDSTLRTIQT QLKSMLSNTV SSSSYKTLAQ IGITTDPSDG KLELDADKLT
AALKKDASGV GALIVGDGKK TGITTTIGSN LTSWLSTTGI IKAATDGVSK TLNKLTKDYN
AASDRIDAQV ARYKEQFTQL DVLMTSLNST SSYLTQQFEN NSNSK
//
