ID C3T952_ECOLX Unreviewed; 309 AA.
AC C3T952;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=DNA replication terminus site-binding protein {ECO:0000256|HAMAP-Rule:MF_00483};
DE Short=Ter-binding protein {ECO:0000256|HAMAP-Rule:MF_00483};
GN Name=tus {ECO:0000256|HAMAP-Rule:MF_00483};
GN ORFNames=C9E67_13275 {ECO:0000313|EMBL:QCL48069.1}, ECs2316
GN {ECO:0000313|EMBL:ACI83236.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:ACI83236.1};
RN [1] {ECO:0000313|EMBL:ACI83236.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=493/89 {ECO:0000313|EMBL:ACI83236.1}, 86-24
RC {ECO:0000313|EMBL:ACI83237.1}, 87-14 {ECO:0000313|EMBL:ACI83238.1},
RC TB182A {ECO:0000313|EMBL:ACI83239.1}, and TW14359
RC {ECO:0000313|EMBL:ACI83240.1};
RX PubMed=19439656; DOI=10.1073/pnas.0812949106;
RA Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J.,
RA Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E.,
RA Sawyer S.A., Whittam T.S., Tarr P.I.;
RT "A precise reconstruction of the emergence and constrained radiations of
RT Escherichia coli O157 portrayed by backbone concatenomic analysis.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009).
RN [2] {ECO:0000313|EMBL:QCL48069.1, ECO:0000313|Proteomes:UP000298553}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=143 {ECO:0000313|EMBL:QCL48069.1,
RC ECO:0000313|Proteomes:UP000298553};
RA Bono J.L., Arthur T.M.;
RT "WGA of Escherichia coli O157:H7: comparison of multiple isolates.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Trans-acting protein required for termination of DNA
CC replication. Binds to DNA replication terminator sequences (terA to
CC terF) to prevent the passage of replication forks. The termination
CC efficiency will be affected by the affinity of this protein for the
CC terminator sequence. {ECO:0000256|HAMAP-Rule:MF_00483}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00483}.
CC -!- SIMILARITY: Belongs to the Tus family. {ECO:0000256|HAMAP-
CC Rule:MF_00483}.
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DR EMBL; EU900685; ACI83236.1; -; Genomic_DNA.
DR EMBL; EU900686; ACI83237.1; -; Genomic_DNA.
DR EMBL; EU900687; ACI83238.1; -; Genomic_DNA.
DR EMBL; EU900688; ACI83239.1; -; Genomic_DNA.
DR EMBL; EU900689; ACI83240.1; -; Genomic_DNA.
DR EMBL; CP028607; QCL48069.1; -; Genomic_DNA.
DR RefSeq; WP_001322334.1; NZ_WJRH01000002.1.
DR PATRIC; fig|562.7073.peg.171; -.
DR Proteomes; UP000298553; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006274; P:DNA replication termination; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.54.10; -; 1.
DR Gene3D; 3.50.14.10; Replication terminator Tus, domain 1 superfamily/Replication terminator Tus; 1.
DR HAMAP; MF_00483; Rep_term_Tus; 1.
DR InterPro; IPR008865; DNA_replication_term_site-bd.
DR InterPro; IPR036381; Tus_dom1.
DR InterPro; IPR036384; Tus_sf.
DR NCBIfam; TIGR02648; rep_term_tus; 1.
DR Pfam; PF05472; Ter; 1.
DR SUPFAM; SSF56596; Replication terminator protein (Tus); 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00483};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_00483};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00483}.
SQ SEQUENCE 309 AA; 35756 MW; A7C890BBE86E873B CRC64;
MARYDLVDRL NTTFRQMEQE LAAFAAHLEQ HKLLVARVFS LPEVKKEDEH NPLNRIEVKQ
HLGNDAQSQA LRHFRHLFIQ QQSENRSSKA AVRLPGVLCY QVDNLSQAAL VSHIQHINKL
KTTFEHIVTV ESELPTAARF EWVHRHLPGL ITLNAYRTLT VLHDPATLRF GWANKHIIKN
LHRDEVLAQL EKSLKSPRSV APWTREEWQR KLEREYQDIA ALPQNAKLKI KRPVKVQPIA
RVWYKGDQKQ VQHACPTPLI ALINRDNGAG VPDVGELLNY DADNVQHRYK PQAQPLRLII
PRLHLYVAD
//
