ID C3TTP1_9CRYT Unreviewed; 215 AA.
AC C3TTP1;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=90 kDa heat shock protein {ECO:0000313|EMBL:ACN22064.1};
DE Flags: Fragment;
GN Name=hsp90 {ECO:0000313|EMBL:ACN22064.1};
OS Cryptosporidium suis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=396558 {ECO:0000313|EMBL:ACN22064.1};
RN [1] {ECO:0000313|EMBL:ACN22064.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=14289 {ECO:0000313|EMBL:ACN22064.1};
RX PubMed=19168758; DOI=10.1128/EC.00294-08;
RA Feng Y., Dearen T., Cama V., Xiao L.;
RT "90-kilodalton heat shock protein, Hsp90, as a target for genotyping
RT Cryptosporidium spp. known to infect humans.";
RL Eukaryot. Cell 8:478-482(2009).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the heat shock protein 90 family.
CC {ECO:0000256|ARBA:ARBA00008239}.
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DR EMBL; FJ153252; ACN22064.1; -; Genomic_DNA.
DR AlphaFoldDB; C3TTP1; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0051082; F:unfolded protein binding; IEA:InterPro.
DR CDD; cd16927; HATPase_Hsp90-like; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR019805; Heat_shock_protein_90_CS.
DR InterPro; IPR001404; Hsp90_fam.
DR InterPro; IPR020575; Hsp90_N.
DR PANTHER; PTHR11528:SF97; ENDOPLASMIN; 1.
DR PANTHER; PTHR11528; HEAT SHOCK PROTEIN 90 FAMILY MEMBER; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF00183; HSP90; 1.
DR PRINTS; PR00775; HEATSHOCK90.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS00298; HSP90; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Stress response {ECO:0000313|EMBL:ACN22064.1}.
FT DOMAIN 5..160
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
FT REGION 192..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACN22064.1"
FT NON_TER 215
FT /evidence="ECO:0000313|EMBL:ACN22064.1"
SQ SEQUENCE 215 AA; 24068 MW; 41FFFEC7FE046EFA CRC64;
SLYSQKDVFL RELLSNSADA LEKARFISVT DDSFLGEQQE LEIRVSFNSD KRTITISDTG
IGMTRHDLVT NLGTVAKSGT ANFLESLAKG GDLNLIGQFG VGFYASYLVS DRVTVISKNN
EDKQYVWESS ADGSFRVSLD PRGNTIKRGT TIVLSLKEDA TEFMNFSKLK DLALRYSQFI
NFPIYIYNPE GVNKSEKDES GEKESKGRWE QVNVE
//
