ID   C3U4S7_CAERE            Unreviewed;       899 AA.
AC   C3U4S7;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE   Flags: Fragment;
GN   Name=odr-1 {ECO:0000313|EMBL:ACQ44106.1};
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234 {ECO:0000313|EMBL:ACQ44106.1};
RN   [1] {ECO:0000313|EMBL:ACQ44106.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PB257 {ECO:0000313|EMBL:ACQ44106.1};
RX   PubMed=19001295; DOI=10.1534/genetics.107.082651;
RA   Jovelin R., Dunham J.P., Sung F.S., Phillips P.C.;
RT   "High nucleotide divergence in developmental regulatory genes contrasts
RT   with the structural elements of olfactory pathways in caenorhabditis.";
RL   Genetics 181:1387-1397(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001436};
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DR   EMBL; FJ455612; ACQ44106.1; -; Genomic_DNA.
DR   AlphaFoldDB; C3U4S7; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   PANTHER; PTHR11920:SF355; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-10-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   4: Predicted;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        363..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          432..715
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          783..899
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACQ44106.1"
FT   NON_TER         899
FT                   /evidence="ECO:0000313|EMBL:ACQ44106.1"
SQ   SEQUENCE   899 AA;  102479 MW;  D61F58AA4A2B3B20 CRC64;
     INRQTGCTGD NSVKAASYAI NAVASKTSGD LDFVFVGPTC TTDIRTIGDF AELWKTPVIG
     YEPVFEARGV QELTSVINVA QFSVGGVAQT LVFLMKELNQ SEITLIGSVK VLPNGFSLSN
     DLRNYNKVMK SFTIREYFEI DENNADWSKV DYRLRHGARM IVICVDFYDI YSSLYNIAIR
     TLSGFRFIIV IILNKPPDEV LNQPNIKNLL YGSNAFIISP LQEQFSDALS YMQNVLPTLA
     DEQFTSFHRI YHACYAYCVG SMNGVETQTD NYHQAMRGKV VTTKYGAFTF DNSGSVLTNY
     AVFTVDPADM TFASVMTLKS TPKDCDYYDC FELTANKTPD LLWTLKDMDP PDECVARNAC
     SNYIPHVIAG IIIVVSLLCT AVVYLKQRTH RMNIYKMTWK VANHTLKIIV NKNADAKMQR
     ELENRSSKDE NALTSRRRVF GSYALVGTQR AEYLQFKQEK KIIFPEETLD YLYTLRQLQH
     ENLAKFYGIQ CNDDNVTTFT VLHLLVERGT LEELCLDRDF GMDETFKSAF MRDILKGLQF
     LHKASFGYHG HLHAATCLID INWVLKLALY GVTNFIVDCM DNKNIRLPDH AAPMITYPQY
     VCFPPEHIRE YDETGKLPPR IVRGSPKGDI YCVGMIFYMM IEREDPYMLI HSLERPNPAL
     VKEIMDEGKM PRMPVEHNLE GKLLEKCKDC WNRNPMMRPD IKSIVETIAV VYPTAKGNLV
     DQMIRMSEKW ADELEDMVAI RTADLAAAQF QTMKLLNEML PASVAQDLKN GIVRPPRSYE
     SATVMFVQLC EFYALMKRSK PDEVINFLND IFDQFDKVVK RHDAYKVETT GETYMVASGV
     PHENEGRHIF EVAEISLEIR AVSYTYILPH DKDYKLRIRI GFHAGPLAAG VIGIRSPRY
//