ID C3UFX1_9HIV1 Unreviewed; 234 AA.
AC C3UFX1;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Pol protein {ECO:0000313|EMBL:ACP02826.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACP02826.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACP02826.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACP02826.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I70clone41 {ECO:0000313|EMBL:ACP02826.1};
RA Foley B.T.;
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACP02826.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I70clone41 {ECO:0000313|EMBL:ACP02826.1};
RX PubMed=19119321; DOI=10.1371/journal.pone.0004096;
RA Moorthy A., Gupta A., Bhosale R., Tripathy S., Sastry J., Kulkarni S.,
RA Thakar M., Bharadwaj R., Kagal A., Bhore A.V., Patil S., Kulkarni V.,
RA Venkataramani V., Balasubramaniam U., Suryavanshi N., Ziemniak C.,
RA Gupte N., Bollinger R., Persaud D.;
RT "Nevirapine resistance and breast-milk HIV transmission: effects of single
RT and extended-dose nevirapine prophylaxis in subtype C HIV-infected
RT infants.";
RL PLoS ONE 4:E4096-E4096(2009).
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DR EMBL; FJ523244; ACP02826.1; -; Genomic_DNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 41..231
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACP02826.1"
FT NON_TER 234
FT /evidence="ECO:0000313|EMBL:ACP02826.1"
SQ SEQUENCE 234 AA; 27063 MW; F0A6C3450914AB35 CRC64;
PIETVPVKLK PGMDGPKVKQ WPLTEEKIKA LTAICDEMEK EGKITKIGPE NPYNTPIFAI
KKKDSTKWRK LVDFRELNKR TQDFWEVQLG IPHPAGLKKK KSVTVLDVGD AYFSVPLYED
FRKYTAFTIP STNNETPGIR YQYNVLPQGW KGSPAIFQAS MTKILEPFRA QNPEIVIYQY
MDDLYVGSDL EIGQHRAKIE ELRGHLLKWG FTTPDKKHQK EPPFLWMGYE LHPD
//
