ID C3UWD6_LUTAR Unreviewed; 279 AA.
AC C3UWD6;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 22-FEB-2023, entry version 43.
DE SubName: Full=MHC class II antigen-associated invariant chain {ECO:0000313|EMBL:ACO82381.1};
OS Lutjanus argentimaculatus (Mangrove red snapper) (Sciaena argentimaculata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Lutjaniformes; Lutjanidae; Lutjanus.
OX NCBI_TaxID=211834 {ECO:0000313|EMBL:ACO82381.1};
RN [1] {ECO:0000313|EMBL:ACO82381.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22210546; DOI=10.1016/j.dci.2011.12.011;
RA Zhou J., Li L., Cai Z.H.;
RT "Identification of putative cathepsin S in mangrove red snapper Lutjanus
RT argentimaculatus and its role in antigen presentation.";
RL Dev. Comp. Immunol. 37:28-38(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR EMBL; FJ772422; ACO82381.1; -; mRNA.
DR AlphaFoldDB; C3UWD6; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035718; F:macrophage migration inhibitory factor binding; IEA:InterPro.
DR GO; GO:0042289; F:MHC class II protein binding; IEA:InterPro.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0070206; P:protein trimerization; IEA:InterPro.
DR CDD; cd00191; TY; 1.
DR Gene3D; 1.10.870.10; MHC class II-associated invariant chain, trimerisation domain; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 1.
DR InterPro; IPR043530; CD74_antigen.
DR InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
DR InterPro; IPR022339; MHC_II-assoc_invar_chain.
DR InterPro; IPR011988; MHC_II-assoc_invariant_trimer.
DR InterPro; IPR036613; MHCII_invariant_trimer_sf.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR14093; HLA CLASS II GAMMA CHAIN; 1.
DR PANTHER; PTHR14093:SF17; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN; 1.
DR Pfam; PF09307; MHC2-interact; 1.
DR Pfam; PF08831; MHCassoc_trimer; 1.
DR Pfam; PF00086; Thyroglobulin_1; 1.
DR PIRSF; PIRSF001992; CD74_antigen; 1.
DR PRINTS; PR01990; CD74ANTIGEN.
DR SMART; SM00211; TY; 1.
DR SUPFAM; SSF48305; Class II MHC-associated invariant chain ectoplasmic trimerization domain; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 1.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR001992-1}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..254
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DISULFID 197..215
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1"
FT DISULFID 226..233
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1,
FT ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 235..254
FT /evidence="ECO:0000256|PIRSR:PIRSR001992-1"
SQ SEQUENCE 279 AA; 31280 MW; 8EFC659BBCD9F681 CRC64;
MASSPEDAPL ARGSLAGSEE ALVLPGRPGG GSNSRALKIA GLTTLACLLL ASQVFTAYMV
FGQRQQIHTL QRNSEKMGRQ LTRSSQAVAP MRMHMPMSSL PLLRDFSSDD DSKTPLTKLQ
DTVVSVEKQV KDLVQDSQLP QFNETFLANM RSLKHQLNET EWQSFETWMR YWLIFQMAQQ
QPPPPTAQPA SLIKTKCQME AAPGPSKIGS YKPQCDEQGR YKPMQCWHAT GYCWCVDEAG
TTIEGTMMRG RPDCQRGTFP RRMMMAPRLM QKTISINDE
//
