ID C3W981_HUMAN Unreviewed; 335 AA.
AC C3W981;
DT 16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Spleen tyrosine kinase {ECO:0000313|EMBL:CAY55930.1};
GN Name=SYK {ECO:0000313|EMBL:CAY55930.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAY55930.1};
RN [1] {ECO:0000313|EMBL:CAY55930.1}
RP NUCLEOTIDE SEQUENCE.
RA Muschen M.;
RT "Inactivation of pre-B cell receptor signaling in acute lymphoblastic
RT leukemia.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FN391892; CAY55930.1; -; mRNA.
DR AlphaFoldDB; C3W981; -.
DR MaxQB; C3W981; -.
DR PeptideAtlas; C3W981; -.
DR ChiTaRS; SYK; human.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd10401; SH2_C-SH2_Syk_like; 1.
DR CDD; cd09938; SH2_N-SH2_Zap70_Syk_like; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR023420; Kinase_SYK/ZAP-70_inter-SH2_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035838; SYK/ZAP-70_N_SH2.
DR PANTHER; PTHR19969:SF5; ADAPTER MOLECULE CRK; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 2: Evidence at transcript level;
KW Kinase {ECO:0000313|EMBL:CAY55930.1};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Transferase {ECO:0000313|EMBL:CAY55930.1}.
FT DOMAIN 15..107
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 168..259
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 335 AA; 37399 MW; 3A15FDA220348A0A CRC64;
MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK
AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF
EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ
IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL
VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK
PGHRKVLKQP LLAVQLSVLP CPREPAREYC VIQSV
//
