ID C3XW28_BRAFL Unreviewed; 1503 AA.
AC C3XW28;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=MACPF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRAFLDRAFT_63809 {ECO:0000313|EMBL:EEN67562.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN67562.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN67562.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN67562.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
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DR EMBL; GG666471; EEN67562.1; -; Genomic_DNA.
DR RefSeq; XP_002611552.1; XM_002611506.1.
DR eggNOG; KOG2806; Eukaryota.
DR InParanoid; C3XW28; -.
DR CDD; cd10909; ChtBD1_GH18_2; 3.
DR CDD; cd00064; FU; 1.
DR CDD; cd00108; KR; 1.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR003609; Pan_app.
DR PANTHER; PTHR46549:SF1; F5_8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46549; MACPF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00051; Kringle; 1.
DR Pfam; PF01823; MACPF; 2.
DR Pfam; PF00024; PAN_1; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00261; FU; 1.
DR SMART; SM00130; KR; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00473; PAN_AP; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF57440; Kringle-like; 1.
DR PROSITE; PS00021; KRINGLE_1; 1.
DR PROSITE; PS50070; KRINGLE_2; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50948; PAN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1503
FT /note="MACPF domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002934373"
FT DOMAIN 376..712
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 1105..1183
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 1402..1496
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT REGION 179..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1106..1183
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 1127..1166
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 1155..1178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
SQ SEQUENCE 1503 AA; 164143 MW; 61261A3D788226C1 CRC64;
MKRAVGTEVS LVLMLAVSVS LIAAAPREVP SSRAGHLRSK RSLSSVDDSV AVEQEHLSTT
PDHRVVRRAL HDALPGDLQG ALQAAAAEDA PEDVKDKRFL PAIAGLAGKL LSSGAVAKAG
GLVGKAGELG ANLAGVQDLI GVLGDVKNMV PDFMAQGAER EAEVEAEVEK EVARETVEKV
LGEVGSRGES DEDSTKGEHG KRKARIRYRN RGDDENNEGG DDGEHEVKAD IEFDPEKGMV
ASNMFAPPGM HMKLDVQEDP KKQTEPDQSS QPMSFSYPMG MGPALVNGCF GTGYKAGDPC
FNKKDLIPAC FNMMEGCGYI GVGFDGRGDY SSKSRKKSVV QRNCKNLATY HDEDVPDNMN
VHGIFDTEVA SFVFESRESY RHYIQMKAGM SFSSFVFKAA VDTVYGSKTS VSKQQFMSLI
QCNVVRYEIF LDEISPDTLS LAFLRDFLSL PFNFVMGKAK LQKFILRYGT HFIKSAKFGG
SFRLFKTQEA SKAAVDTVYG SKTSVSKQQF MSLIQCNVVR YEIFLDEISP DTLSLAFLRD
FLSLPFNFVM GKAKLQKFIL RYGTHFIKSA KFGGSFRLFK TQEASKVSSF QEFSEKSEAS
LNAIFANAKA EFGLESSSGS SQSSKTSGTH VTVEGGDQEV ASIVADFYST SFKDTFAEWL
KSIPKFPKPI EMFMGTMSEL LDMNYKLLFP FDIKDAADGC FSKTYCEFTS AEKFEEAMDK
KRLALERAIA VYMEEGPVPT TDFHLEGGKP GCVTKALKIH GGASGVTHPT WLELINGDTY
KVSCFGFVMT YDEEMGKFTV TPEDQAASVQ ALGKLPRDYK YMRVARAEYI SPLEHAKAKG
GALAGILEAP CSVKWSNSYQ ISPADTGGKC LYFLAASAGD IFAVFSAIPR DKTTWYHLQI
SYQGVALYKG MKLVKYEAAK SARSLGDPKL FRPYFICLEE DMEKKTTYIT YGIASEASEK
GLVYMVYLDD SPPLGIQFYS FGSGEKDVEV MDVRVIEGGG NRHVVCTGGT VLKDGLCVED
CHPECIGCIP SFPGSKLDTE CRACKHFSMY SRCVSECPAD MELTDNGKRC VCKGLVVELK
EGTTQCASSC PAKYDLATDG KTCKCCLIGK GETYRGNIAV TKSGKTCQRW GSQYPHKHTR
KAGTKPEDAL YNNYCRNPSG EDTIWCYTTD SEKRWDYCDK RACDGPKWRI DGKCGKNFPA
PGGLPAQCDP KSNKPCCSSE GTCGGTDAHC TCEGCVDYRP KWRDDGKCGK NFPAPGASPG
ECNPNSDKPC CSSEGTCGNT DAHCYCSGCV NYFKGIPPWR NDGKCGEKFP APEGSPGQCN
PKSDKPCCSS WGTCGNTYAH CKCSGCVDYG PKKWRSDGRC GSRHYPAPGA NPGQCNPESS
GPCCSPAFWC GGSHAHCKCS GCVNYGAKTS LSWFDHYDKK GLPGHNDEMI ARISVEECAK
RCLAGTSIVP AGSCLSFDYD ATYKKCMLSK VSKDTPGANL ADSDPPERYD YYNRRGTDIF
FQS
//
