ID C3XXU3_BRAFL Unreviewed; 1152 AA.
AC C3XXU3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=BRAFLDRAFT_63818 {ECO:0000313|EMBL:EEN67553.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN67553.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN67553.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN67553.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR EMBL; GG666471; EEN67553.1; -; Genomic_DNA.
DR RefSeq; XP_002611543.1; XM_002611497.1.
DR AlphaFoldDB; C3XXU3; -.
DR STRING; 7739.C3XXU3; -.
DR MEROPS; C85.002; -.
DR eggNOG; KOG2605; Eukaryota.
DR InParanoid; C3XXU3; -.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:0004577; F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0019538; P:protein metabolic process; IEA:UniProt.
DR CDD; cd22794; OTU_OTUD4; 1.
DR Gene3D; 3.90.70.80; -; 1.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR PANTHER; PTHR12419; OTU DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12419:SF117; PROTEIN OVARIAN TUMOR LOCUS-RELATED; 1.
DR Pfam; PF02338; OTU; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50802; OTU; 1.
PE 4: Predicted;
FT DOMAIN 28..149
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT REGION 188..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 327..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1096..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..621
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1122
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 127752 MW; DB26FBBF0C73BA18 CRC64;
MSVVRGRKSP KAAESLQAMD DYLSSLGLVR KPIAKDGSCL FRAVAEQVFH CQARHLEVRE
ACVRYMDRNR DIFEAFVPGP FDHHLWTLQN PKEWAGQVEI SALSLMYKCD FIIYQDVGRP
PARVTENGFA DKVVLCFSHG NHYDSVYPKQ FQIDAAMCQS LVYELLYKDV FKMDHDIAVV
KDMLGNKQQK IRKDSTSESE SSPSKNCGSD KPDSELEGST ELDVSTESDK SRDNTERPNE
KATQANGAVE YSKKDGRRFP LPFKVAKALD PEFYRNVEYD TWMDSKKEQQ RQDMHLATMM
QYAPGDKCQE NGIPPFMVQR VQPSLPPRLQ HEGQYSPKYH HHHGREYQGR DYQGRDYQGR
DYQSREYQGR EYQGRDRDYQ PRDRDREFQR PPHGQRYNGQ ARNQPPRFMR QDQMDGRGPG
PRPGSRYQYS HGRGRGRGRN TPTPPPGPPQ GEMDEKQAIE ESIVLYELQQ RDPDAFPALP
TSNGQVQHVQ SNTVWGRGRG RGMGRRTPTP PPPSTTPSDG GHSMTMEEGS LCSSMQELNM
NERASPDGER ICSPVSHQME VPPMKRVMTP TKEFVPRSSR TPSPYQNPTP PLQSQSANAE
ISSSNSGSNQ QMSTDSTSSP ASTPNTPPPQ TVAPNGYVPY MQPMHVPFYP IMIQATDNLT
GPVNLNFGPS RDPYGNDLPH SDVSTLRFFY NLGIEYYRCC MSMMAIQHQQ QEAAMANAYF
YNQAQGQVQP QYQPASSTDG QNSSGQQAQE GEDPQQEGSD QLPPNGQSQD KPLPQGAHVY
TSASSFNPGN PPVDYHTGAG SDYPPGKTNK SCSDDNSNDS VGNNKDVSVS RSNSMTSVQS
SGDSASMNVQ YGSDSVCGSS VSYVQPSPNA LQQTSSSTTV GSEDSSPDYT DSGVASEGSG
SQSSIPRPTS LGPGLPKRHY MEHRGSPKLI PGRWSTPERS GSSDSLNQEA FPMGRPPYGP
KRGPRDRQPG FYRPSYFPNR PYMSQQPPRR QYEGQPLYHP QLYSNPVRYS NPTHHMSQPQ
QYYMNQYTGP SRMALHGNMG GQPAGMYNRA AGMYSHPSQQ LNVPPGVTSV PYPPMSPSLH
VPAAALHAPN IASSPSATGQ YYPAQAPGPV DPNPPGSQGP TPIPVPSSAA NATHRSQAIY
RILPVGKKLA QN
//
