ID C3Y3M0_BRAFL Unreviewed; 1496 AA.
AC C3Y3M0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Limbin-like {ECO:0008006|Google:ProtNLM};
GN ORFNames=BRAFLDRAFT_129933 {ECO:0000313|EMBL:EEN64896.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN64896.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN64896.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN64896.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; GG666484; EEN64896.1; -; Genomic_DNA.
DR RefSeq; XP_002608886.1; XM_002608840.1.
DR STRING; 7739.C3Y3M0; -.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR InParanoid; C3Y3M0; -.
DR GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 555..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1117..1141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 723..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 938..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1220..1305
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1419..1447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1496 AA; 169463 MW; 34BDEA1F9DFA4641 CRC64;
MEGNDSVITY GNDLSTSATT KITASADGEK LNFDFGNVAN GAATSQDITI ATPFTVLSIN
NVQDILTFEA APTTNGTLQA VNTSFIVIGP QLEIIFTELN NSGPIEAGDV VHLQVVLQHT
GLSTENATNL QLRGSIYPGG TSAATIVTSS VSISSGPYNN SFTTDVLNSG GNLDFGLLPV
GETVTILLWF EALDGLLINR DVQLSLRLRY VDLEGHNLEA WGTESKATRS LTFNDQTKFT
LNVENNVGVD QVVEVNTAFL MPHGTLAASL ELEFQSDALG PDNILLVRGD LPQSEEVNFA
SDVAPVDLLS QNRRRRKRQI FIPATVPIIR TWNVGDIVYP SSLNGRGVDT SVSMLVSYLV
NLDPTQVQNG VPFSLTATLR AAGTAIPLGM RTFVLGLPEL QMDQTVQIAD DTTNPDEVRI
NVTVSHTAQS SADAFDVTIF CNATGLTIFN YRNMIPIFVS PEVTVQGSEI TVTRTHLPLG
EELLLSFQAE MECKERECAE SSPNLTIPAN VTYRSVAVQQ AANSTQFQGI DYGPLMDSIC
LGFDLVELTS LFRNYGYIGL ALVVFLLVGI VVGLLCCFLL GRTRGMQVRP LRGRSKKKKG
GLFSGLKNRL KGLGSWFGEL NFASILTFRD ISKMFRWLDN LDIKSSIDLD IKLQGHRLQL
MINSINIQLQ KLRHKGEISR PILDRVQDKF NKAWRALCRR LGEEYQKALS RLHKRLAAKN
KDNVDSLHKK HEEERKQLID RTTNTPEKER RELVKLLDQQ HQVETEELSY RLQLEQAEEE
EKIRKEFELK KRVGLKELQH NLLKDLAEQA ELSEEEAARI MREHKENQAT INRLMDEEMS
RQRMLLEEKL AQRRAMAKAK EHQEDHNKKV LNTLATQQAG IVQEMREDGK LSAEQEQMFK
ERIRREMLAA RERHDKSRES QEAALQKRLA ELKKKRLAEK EAEQRQEVDE FEKKQQEMQS
EGEGDAEDYI DARHQLMSRH VTEMNNLEIS LDKDASDQLD RLTFDLTKMA QDEIVLFKDK
LCAELGSAGL TIFNYRKMIP IFVSPEVTVQ GSEITVTRTH LPLGEELLLS FQAEMECKER
ECAESSPNLT IPANVTYRSV AVQQTANSTQ LFRNYGYIGL ALIVFLLVGI VVGLLCCFLL
GRTRGMQVRP LKRQRYRGSD SEGELDDVSL LKQQLQERIS LLSEESQARM DDDIETIRVE
MLQERAQALK DQEERLGGLL SSLQMERARE LATIEEQREA LNKLTTNLVD ELSDKGVLTD
PECKKVIEQH KKDVDKLEKK LHHQRQRQEE ELKKKLTEKM MQREKSMLQL HEERLREIHS
QEASKTAARF KMAAMKNKYM MESEKQRQKM ERGVEQNLED YRRQWDMKRK QALQEQELKF
ISGLVKTGRF EREELFSVLT LLFPHNTDIS QILEKIYTEE SHSSDESDGG RRKKSRGISR
RESTLALRIR EATLGPYTPP PSTKKKKRKE GSKRLKKPKE PRPDPLGGSE SPDLAH
//
