ID C3YA06_BRAFL Unreviewed; 973 AA.
AC C3YA06;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN ORFNames=BRAFLDRAFT_126363 {ECO:0000313|EMBL:EEN62915.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN62915.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN62915.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN62915.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; GG666493; EEN62915.1; -; Genomic_DNA.
DR RefSeq; XP_002606905.1; XM_002606859.1.
DR AlphaFoldDB; C3YA06; -.
DR STRING; 7739.C3YA06; -.
DR eggNOG; KOG4228; Eukaryota.
DR InParanoid; C3YA06; -.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF151; MYOTACTIN FORM B; 1.
DR Pfam; PF00041; fn3; 4.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 703..724
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 106..204
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 279..376
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 381..486
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 491..578
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 579..684
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 471..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 817..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..959
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 973 AA; 107013 MW; AEB51B77BD266ED6 CRC64;
MAGVAAPFMC SPWQLASHNL SGEDESGLGC PSALFPLSWA RPGVSYDAKS SHTTWQVCSS
SSEGICEIPF LHCESTFDRY EVKVETSNSE SQTTSFYKDE IAKPHPPEDL TVQPDSSTQL
TVRWKMPECA DLGFNSYTCQ VEYTSQQNRT RVSDVSVSFD RHTFKELQNL TPYTLYRVRV
RCKPLFRDTW GEFTSTVEAR TNATDSNGVL LGYCIRVRDV RTDEVMELTV IDSGAQTYTH
TLGNLKLSGY RVDITAYNQE GESPATSLVI PDRAKKPDPP IDLIAMATSD SYLQLSWQPP
AEVGGIETYL ILWCELETDV TCLRPEKNMS VAGNELSIKV IDSWRPLARY RFVVKAVNSA
GQSETSNTAA GYVAQGVPSS PPQNVTVQAE TSKSLLVRWK APPLQDRRGI ITTYRVYYYV
TPTVRGQQMA TVERSVSVNI TDDAQPVQFS LSGLEPFTLY SVRLSAVTSQ GEGNKSLPTG
AQTSQAAPSD PPADVQINDI TVNNITLSWT PPSQPNGIIR YYIIKHGNDT MSDGNHTAFV
LEGLEGDRDY AIQIQGCTAA ETPCGPLSPV ELVRTKVGAP GIVQDLLAQF DPTNGDIIVS
WTPPVLKNGR DISYIVSYGR KDLRNDNTAV TTTMQWTNDK LADTCSDGLE LFFRVHARTR
DPGTGEVFNG PVSTEYLSCD TRPGTSSSSK DVQGLRLALE AKVGIILAVL IACMVGIAAL
VPSLRKMYNK TKNDVPGPAD FITDANQGVY YYIPDEPQTL NNLHIVSEQT GKTPEILDDF
SKLRVERQWS HDSAFGSDYG NNNVDFNVAE QKAHYSVGGS SSGYSDVSDE NAALQSDASK
AENLASDNQQ NDVADYSKLA DVDGNFKDLK VNYVTKQDSK TAEGSKHRTS TQSSTDNLDT
ITDYSKLAAE RDYRKDLAVN YVRNTGPKGN KLEEIPKSEQ CSPKHADIPY RESPSPVKRK
IFDPDNVPYV SNA
//
