ID C3YKM4_BRAFL Unreviewed; 419 AA.
AC C3YKM4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Inositol-tetrakisphosphate 1-kinase {ECO:0000256|ARBA:ARBA00014968};
DE EC=2.7.1.134 {ECO:0000256|ARBA:ARBA00012072};
DE EC=2.7.1.159 {ECO:0000256|ARBA:ARBA00012017};
DE AltName: Full=Inositol 1,3,4-trisphosphate 5/6-kinase {ECO:0000256|ARBA:ARBA00031742};
GN ORFNames=BRAFLDRAFT_63286 {ECO:0000313|EMBL:EEN59092.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN59092.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN59092.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN59092.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the ITPK1 family.
CC {ECO:0000256|ARBA:ARBA00009601}.
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DR EMBL; GG666523; EEN59092.1; -; Genomic_DNA.
DR RefSeq; XP_002603081.1; XM_002603035.1.
DR AlphaFoldDB; C3YKM4; -.
DR STRING; 7739.C3YKM4; -.
DR eggNOG; ENOG502QQS1; Eukaryota.
DR InParanoid; C3YKM4; -.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0047325; F:inositol tetrakisphosphate 1-kinase activity; IBA:GO_Central.
DR GO; GO:0052726; F:inositol-1,3,4-trisphosphate 5-kinase activity; IBA:GO_Central.
DR GO; GO:0052725; F:inositol-1,3,4-trisphosphate 6-kinase activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0032957; P:inositol trisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 2.
DR InterPro; IPR008656; Inositol_tetrakis-P_1-kinase.
DR InterPro; IPR040464; InsP(3)kin_ATP-grasp.
DR InterPro; IPR041429; ITPK1_N.
DR PANTHER; PTHR14217; INOSITOL-TETRAKISPHOSPHATE 1-KINASE; 1.
DR PANTHER; PTHR14217:SF1; INOSITOL-TETRAKISPHOSPHATE 1-KINASE; 1.
DR Pfam; PF05770; Ins134_P3_kin; 2.
DR Pfam; PF17927; Ins134_P3_kin_N; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 49..115
FT /note="Inositol-tetrakisphosphate 1-kinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17927"
FT DOMAIN 142..320
FT /note="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp"
FT /evidence="ECO:0000259|Pfam:PF05770"
FT DOMAIN 351..394
FT /note="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp"
FT /evidence="ECO:0000259|Pfam:PF05770"
FT REGION 253..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 45893 MW; 7A11916A18C42E68 CRC64;
MTFSAKIEGV IVTAAGRYGA KRRRRFGLVI TDLCHGDFGK VPLGQNNGCK NSSIDLVKVD
VNRSVAAQGP FDVFIHDFTD IVREAEEGDT KAEMFVAELS EYVSRHPNMV VMNPVASWRL
LHDRLGAQGV AAEVVKLLND PDVIVPNRVY LEKSGVKNMM KNLKMAGVTF PFVCKSSSLL
LAEHHKMTLV YGRRGLESLD LPCAAESFTN HSGILHKIYV IGDTHFVYAR PSLKNFAMSD
DLPNVQFSTS DVAKSDSVSP LNAGKRGEPT SQTSPVSDEK ISRISDRMRH VLGSSLIGID
VIVQDGTGNH VIIDVNDFPG NIADEDTQAE MLVTGLEGKH GEPTRETRPV SDEKISRISD
TTRRVLGSSL FGIDVIVQDG TGNHVIIDIN DFPSKYELQA DMGWECVSVN LLPSNSVRQ
//
