ID C3Z7Y3_BRAFL Unreviewed; 348 AA.
AC C3Z7Y3;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Torsin {ECO:0000256|PIRNR:PIRNR038079};
GN Name=LOC118420495 {ECO:0000313|RefSeq:XP_035683219.1};
GN ORFNames=BRAFLDRAFT_128102 {ECO:0000313|EMBL:EEN51297.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN51297.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN51297.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN51297.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
RN [2] {ECO:0000313|RefSeq:XP_035683219.1}
RP IDENTIFICATION.
RC STRAIN=S238N-H82 {ECO:0000313|RefSeq:XP_035683219.1};
RC TISSUE=Testes {ECO:0000313|RefSeq:XP_035683219.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|PIRNR:PIRNR038079}.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family. Torsin subfamily.
CC {ECO:0000256|ARBA:ARBA00006235, ECO:0000256|PIRNR:PIRNR038079}.
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DR EMBL; GG666592; EEN51297.1; -; Genomic_DNA.
DR RefSeq; XP_002595285.1; XM_002595239.1.
DR RefSeq; XP_035683219.1; XM_035827326.1.
DR STRING; 7739.C3Z7Y3; -.
DR KEGG; bfo:118420495; -.
DR eggNOG; KOG2170; Eukaryota.
DR InParanoid; C3Z7Y3; -.
DR OMA; YYDVVDE; -.
DR OrthoDB; 5087at2759; -.
DR Proteomes; UP000001554; Chromosome 8.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049337; TOR1A_C.
DR InterPro; IPR010448; Torsin.
DR InterPro; IPR017378; Torsin_1/2.
DR PANTHER; PTHR10760:SF2; LD13476P-RELATED; 1.
DR PANTHER; PTHR10760; TORSIN; 1.
DR Pfam; PF21376; TOR1A_C; 1.
DR Pfam; PF06309; Torsin; 1.
DR PIRSF; PIRSF038079; Torsin_2A; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR038079-1};
KW Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR038079};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR038079-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001554};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..348
FT /note="Torsin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041197975"
FT DOMAIN 278..333
FT /note="Torsin-1A C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21376"
FT BINDING 109..116
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR038079-1"
SQ SEQUENCE 348 AA; 39664 MW; 1C9E6DE54C87C856 CRC64;
MIMSSYIKLF FVLNIFLTVS LAIEPITTGL AVGVGVTASA LLAGFNHFKC NVVECCDNNW
FIPNITGLRT SLQDKLHGQH LVVDTVAKAV KGHIRNKNPS KALVLSFHGW TGGGKNFVSK
MIAENLFVKG MMSRHVHLFV ATLHFPHKDR VETYKDQLRE WIKGNTSDCP HSIFVFDEMD
KLPEGLLDAV KPYIDHYTEI NGVDYRKTIF ILLSNTAGNT ITQRTYQHWQ EGRKREDISL
KEMDDLILKG SFNEKGGLWH SSLIEKNLID VFIPFLPLER QHVKLCIRDD LRAKGHTVTE
DVVTKVADEL QYFPDREQLY SKSGCKRVSQ KVDLIMEEVS QTVEEIMR
//
