ID C3Z940_BRAFL Unreviewed; 598 AA.
AC C3Z940;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
GN ORFNames=BRAFLDRAFT_244565 {ECO:0000313|EMBL:EEN50952.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN50952.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN50952.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN50952.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG666598; EEN50952.1; -; Genomic_DNA.
DR RefSeq; XP_002594941.1; XM_002594895.1.
DR AlphaFoldDB; C3Z940; -.
DR STRING; 7739.C3Z940; -.
DR eggNOG; KOG0994; Eukaryota.
DR InParanoid; C3Z940; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0043256; C:laminin complex; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0070831; P:basement membrane assembly; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF419; NETRIN-4 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 16..247
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 320..382
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 383..437
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 476..597
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 350..359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 409..418
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 421..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 598 AA; 67126 MW; C03A537A394E2843 CRC64;
MFFDIVSNVA YRSRCDRHSC HPPPGNLAIG RLLRTSTTCG ENGGEHFCSI SSSSSCSKVK
CYKCHSGRKN RAHPPWHMTD TGAGHRGTWW QSKNNGGAET IQLDLESRFY FTHLVMVFRT
PRPAAMVLER SSDYGKTWRT YSYFARNCTE TFGLREGVNP EGSLCTSRYS APDPCTRGEV
IFRVLPVGSN HSISDPYSLH AQDLMTITNI RMRLLKRQSC SCPTEEVQEK PYKFAHFAVY
NLIISGSCFC NGHADVCVPI DGRKVVGPGG QSALLKVNGK CVCRHNTAGV NCERCAPLYN
NQPWKPGNGR TGKKNMCEKC ECNSHADSCH FDLNVWRATN GKTGGVCDDC QHNTMGRRCH
RCRPGYYQDP TRDKAHPQIC KRCECDPVGT VDGVSGKRPC NMVTGRCKCK NGVTGTRCDR
CRPNYWGFGK IRNGCQKCNC GFQDICDQET GACRPIKKET EPDFQQYISL QRTDHCKCLE
ETLKDPELLC DKHYDFALRA TVKDAVDLGQ HVAVTVQIRK VILSKNVSVE KGEAKVWPTS
WTEHGCTCPI MNVGEEYLLT GFEDVDNNRL IVNETSYVKE WAQATTRDIT RVLRKVCT
//
