ID C3ZAV0_BRAFL Unreviewed; 956 AA.
AC C3ZAV0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BRAFLDRAFT_118819 {ECO:0000313|EMBL:EEN49987.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN49987.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN49987.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN49987.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; GG666603; EEN49987.1; -; Genomic_DNA.
DR RefSeq; XP_002593976.1; XM_002593930.1.
DR AlphaFoldDB; C3ZAV0; -.
DR STRING; 7739.C3ZAV0; -.
DR eggNOG; KOG1027; Eukaryota.
DR InParanoid; C3ZAV0; -.
DR GO; GO:1990604; C:IRE1-TRAF2-ASK1 complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IBA:GO_Central.
DR GO; GO:0036498; P:IRE1-mediated unfolded protein response; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 5.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..956
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002934450"
FT DOMAIN 474..759
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 762..890
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 311..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 956 AA; 107170 MW; 22D8C1BC3FD3EED4 CRC64;
MFLWLQFFLS LVLSSLEVSS ERATPTTLSV PESLLFVSTL DGTLYAISHR TGTVRWLLKE
DPVIQVPSDI TTGPTFLPDP KDGSLYVFGG AGTSEGLAKL PFTIPELVNA SPCKSSDGIL
YTGRKTDTWY AIDPVTGIKQ QKITMEGTDR VCPSSDASTL FLGRTEYNIA MFDSKTRELR
WNVTYMDYSA HVAKDSSDYP LRHYCSSSDG LMITVDSVTG KVLWDANFTS PVIAMYAWDK
DEMKKVPFTN IAMETLEQIV GQVRVPAWGE LIMGKSQETK LLPTLFVGEY AHGLYAIPSL
VDEDVTVSPR NEVPLLDGPT PPPSLPTTTS IPSTGMHSES ARATTKRRGS VVLGHHESPL
VVNSRLQPSR HIPHSTGDPS LPIREGGSRK NRSNPDVLID YDESGIPDWL ILVNGIVIGA
IVLVVIMVLV RQYRGEPQSS RASRLSEAST ASFGEGYPNE ESEEGYHQVG KIMFKPEDIL
GYGCEGTIVY RGRFDKRDVA VKRILPECFS FADREVNLLR ESDEHPHVIR YFCTESDKQF
KYIALELCAA TLQQYVQNKD FERHGLEPVD LLYQAVSGID HLHSLGIVHR DVKPHNVLIS
QPNAHGQVKA MISDFGLCKK LAQGRHSFSR RSGAAGTEGW IAPEMLDDEK RTTCSVDIFS
AGCVVYYVLT MGKHPFGDSL RRQANILSGE YSLDDLCVKE KAKEVSLSPM WTRKVPCPAV
LPRIDESQRV VAKELIKMMI RQDPTMRPTA PSVLKSPFFW SKEKQLQFFQ DVSDRVEKEA
LDGAIVTELE FGGRTVVKGD WRSRIGVELQ ADLRKFRSYK GGSVRCLLRA MRNKKHHYLD
LPLDVRRALG RVPDEFVSYF TQRFPMLLWH TYKAMLCCKN ERVFHGYYEK DDKSLAPTIL
RQRNKDDSKQ GVEEVTSENG QQQKETLKNS EEVDKNVLVD KGNNAQTQQG NNNVQS
//
