ID   C3ZGV2_BRAFL            Unreviewed;       511 AA.
AC   C3ZGV2;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=Zinc transporter ZIP14 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BRAFLDRAFT_277179 {ECO:0000313|EMBL:EEN48328.1};
OS   Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC   Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC   Branchiostomatidae; Branchiostoma.
OX   NCBI_TaxID=7739;
RN   [1] {ECO:0000313|EMBL:EEN48328.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN48328.1};
RC   TISSUE=Testes {ECO:0000313|EMBL:EEN48328.1};
RX   PubMed=18563158; DOI=10.1038/nature06967;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA   Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA   Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA   Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA   Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA   Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA   Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA   Satoh N., Rokhsar D.S.;
RT   "The amphioxus genome and the evolution of the chordate karyotype.";
RL   Nature 453:1064-1071(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000256|ARBA:ARBA00006939}.
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DR   EMBL; GG666620; EEN48328.1; -; Genomic_DNA.
DR   RefSeq; XP_002592317.1; XM_002592271.1.
DR   AlphaFoldDB; C3ZGV2; -.
DR   STRING; 7739.C3ZGV2; -.
DR   eggNOG; KOG2693; Eukaryota.
DR   InParanoid; C3ZGV2; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140410; F:monoatomic cation:bicarbonate symporter activity; IBA:GO_Central.
DR   GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071578; P:zinc ion import across plasma membrane; IBA:GO_Central.
DR   InterPro; IPR003689; ZIP.
DR   PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR   PANTHER; PTHR12191:SF36; ZRT (ZRT), IRT-(IRT-) LIKE PROTEIN TRANSPORTER; 1.
DR   Pfam; PF02535; Zip; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        166..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        195..220
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        235..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        439..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        487..509
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          258..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..286
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  56001 MW;  F559B617D65A577C CRC64;
     MDRSFDTVVL VGTLLVVFSV SSLPVLGSIP KGLGTPDNFT QALLDRYGSG DRLTVQDLQV
     LLWNASRCPG VQQCGRRDEA TGAPVEETGR TEEDICRTTC ITAREVLQIH NMSGDSELNA
     TGLREVCSTL LYSVDRTIGC QSQGEDSIES TEDKHDGSRR PSPAEVWGFG VLSVAIISLC
     SVMGVLVVPF MKKRLYTLLL TFLIALAVGA LSGSALFHLI PQAFDLPIED YTEKAAAVWA
     GIYLFFITER LLKMASKQRQ KPPRHHSHSH GHVFHNPDTE DSSTEDSHSQ KVSIEKFIQC
     LIFFVNNVQS GCLTLTKQVF IDKMTFSFLL QQKRNCCQAL CSNTDTIATV AWMVIFGDGL
     HNLMDGLAIG ASFQVSVFSG ISTSLAVLCE EFPHELGDFA ILLNAGMSVR QAMFYNFLSA
     CSCFAGLIIG IVVGDNSEVG QWIFGLAGGM FLYISLVDMM PEMNAVDEDE EKNLQDSEGK
     SSSLLRFFLQ NLGLLTGFAV MLVLAKFPFE I
//