ID C3ZSM7_BRAFL Unreviewed; 716 AA.
AC C3ZSM7;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Ku domain-containing protein {ECO:0000259|SMART:SM00559};
DE Flags: Fragment;
GN ORFNames=BRAFLDRAFT_164247 {ECO:0000313|EMBL:EEN44429.1};
OS Branchiostoma floridae (Florida lancelet) (Amphioxus).
OC Eukaryota; Metazoa; Chordata; Cephalochordata; Leptocardii; Amphioxiformes;
OC Branchiostomatidae; Branchiostoma.
OX NCBI_TaxID=7739;
RN [1] {ECO:0000313|EMBL:EEN44429.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S238N-H82 {ECO:0000313|EMBL:EEN44429.1};
RC TISSUE=Testes {ECO:0000313|EMBL:EEN44429.1};
RX PubMed=18563158; DOI=10.1038/nature06967;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Putnam N.H., Butts T., Ferrier D.E.K., Furlong R.F., Hellsten U.,
RA Kawashima T., Robinson-Rechavi M., Shoguchi E., Terry A., Yu J.-K.,
RA Benito-Gutierrez E.L., Dubchak I., Garcia-Fernandez J., Gibson-Brown J.J.,
RA Grigoriev I.V., Horton A.C., de Jong P.J., Jurka J., Kapitonov V.V.,
RA Kohara Y., Kuroki Y., Lindquist E., Lucas S., Osoegawa K., Pennacchio L.A.,
RA Salamov A.A., Satou Y., Sauka-Spengler T., Schmutz J., Shin-I T.,
RA Toyoda A., Bronner-Fraser M., Fujiyama A., Holland L.Z., Holland P.W.H.,
RA Satoh N., Rokhsar D.S.;
RT "The amphioxus genome and the evolution of the chordate karyotype.";
RL Nature 453:1064-1071(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
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DR EMBL; GG666674; EEN44429.1; -; Genomic_DNA.
DR RefSeq; XP_002588418.1; XM_002588372.1.
DR AlphaFoldDB; C3ZSM7; -.
DR STRING; 7739.C3ZSM7; -.
DR eggNOG; KOG2326; Eukaryota.
DR InParanoid; C3ZSM7; -.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IBA:GO_Central.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR PIRSF; PIRSF016570; Ku80; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 281..420
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 164..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..716
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEN44429.1"
FT NON_TER 716
FT /evidence="ECO:0000313|EMBL:EEN44429.1"
SQ SEQUENCE 716 AA; 80143 MW; C08DC3E114742245 CRC64;
AMVLVVDVGP LMAQAPPGHV TPLENAKDAI SMLLQRKMFS QSKDEVALIL LGTQETANEL
AGTDDESYLN ITVARPLGQP DFDLLEFVKN DIVPGPVSAD FVDAIVVALD LVRNQTMGKK
FETKRIVLFS NLAGEFTDDQ LEGVINGMKA LECEFNLIGL SLDDDDEDGD MPDQNGAGPP
RKERTPQQRA GTALIRHVIE EVDGVAYSER SALQMLSFFQ KRNVRAAPWK VMLEVGTNLK
IPVRGFIRVK ECKPNSFKKV HARTLSKDDI HTTHEHRLND DEETPVESTI DGYRYGNTIV
PFSTDDESQM KFKTDAKCFD VLGFTRADNV KRQYYMGDSV RCFVAEEGDE PAAVALSAFI
HALYETNMVA IVRYVYNKNS APKVAFLTPH IKPNYECLLC IMLPFMEDMR KYTFSSLHPN
NKNQPSDDQL SAVDDLIDNM NLVMPDKDED GKQQQYLKPK LTFNPHLQRL YQCLSARALN
PDDPQLPPPN QTILNYLQPQ QDLLTQAQPC VDKIKAAFPL EVVTKKKEET TAQNIFGGGD
DAEPAAKKPR LDTDAGGDGG LTMAGLAQGP VTEVGSVRPL EDFRAMISRK DDDKFMEASA
QLQKRIEEIV MESFGDQFYG KAMECLLALR KESAKLGEPD QFNTFLRGFK ETLFNKGRKD
FWDCMVREKV TLISSEESSE TSVSKEEAGK FLEIVEQKTE EPEEMEEAEA EDLVSL
//