ID C4B8H3_POLSE Unreviewed; 380 AA.
AC C4B8H3;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=HMG box transcription factor Sox17 {ECO:0000313|EMBL:BAH58784.1};
DE SubName: Full=S17AA factor {ECO:0000313|EMBL:KAG2458087.1};
GN Name=sox17 {ECO:0000313|EMBL:BAH58784.1};
GN Synonyms=Sox17aa {ECO:0000313|EMBL:KAG2458087.1};
GN ORFNames=GTO96_0017802 {ECO:0000313|EMBL:KAG2458087.1};
OS Polypterus senegalus (Senegal bichir).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Polypteriformes; Polypteridae; Polypterus.
OX NCBI_TaxID=55291 {ECO:0000313|EMBL:BAH58784.1};
RN [1] {ECO:0000313|EMBL:BAH58784.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19433081; DOI=10.1016/j.ydbio.2009.05.543;
RA Takeuchi M., Takahashi M., Okabe M., Aizawa S.;
RT "Germ layer patterning in bichir and lamprey; an insight into its evolution
RT in vertebrates.";
RL Dev. Biol. 332:90-102(2009).
RN [2] {ECO:0000313|EMBL:KAG2458087.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bchr_013 {ECO:0000313|EMBL:KAG2458087.1};
RX PubMed=33545088;
RA Bi X., Wang K., Yang L., Pan H., Jiang H., Wei Q., Fang M., Yu H., Zhu C.,
RA Cai Y., He Y., Gan X., Zeng H., Yu D., Zhu Y., Jiang H., Qiu Q., Yang H.,
RA Zhang Y.E., Wang W., Zhu M., He S., Zhang G.;
RT "Tracing the genetic footprints of vertebrate landing in non-teleost ray-
RT finned fishes.";
RL Cell 0:0-0(2021).
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DR EMBL; AB500933; BAH58784.1; -; mRNA.
DR EMBL; JAATIS010007298; KAG2458087.1; -; Genomic_DNA.
DR AlphaFoldDB; C4B8H3; -.
DR OrthoDB; 2902801at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd22047; HMG-box_SoxF_SOX17; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR033392; Sox7/17/18_central.
DR InterPro; IPR021934; Sox_C.
DR PANTHER; PTHR10270; SOX TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR10270:SF216; TRANSCRIPTION FACTOR SOX-17; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12067; Sox17_18_mid; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51516; SOX_C; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 65..133
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 263..377
FT /note="Sox C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51516"
FT DNA_BIND 65..133
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 43..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 42468 MW; AC6322A86A033611 CRC64;
MSSPDAGYAS DDQTQGRCSM SILMPGIGHC QWTDPLSPLG EAKMKTETCS GTPGSQNRSK
SEPRIRRPMN AFMVWAKDER KRLAQQNPDL HNAELSKMLG KSWKALPVSE KRPFVEEAER
LRVQHMQDHP NYKYRPRRRK QVKRIKRLEP GYLVHGVSDQ SGAPTGTEPR VCVDSIGVNY
HDPCYQGQLT HYREAQAMGA HFDSYSLPTP DTSPLDIVEN DPVFFPSHSQ EDCHMMSYSY
HPQTTDYAPQ EQHANSLLRR HLSTMEQGMM GCHGSLAMYY NQLIVPGHSK AQHGHHAGQL
SPPPETQQHH GNIDALHPPD LLGDVDRSEF EQYLNSAARP DLAYSGQEVG APGPDNGLIS
SVLSDASTAV YYCNYSNAQC
//
