ID C4JTH0_UNCRE Unreviewed; 669 AA.
AC C4JTH0;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=UREG_05759 {ECO:0000313|EMBL:EEP80917.1};
OS Uncinocarpus reesii (strain UAMH 1704).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=336963 {ECO:0000313|EMBL:EEP80917.1, ECO:0000313|Proteomes:UP000002058};
RN [1] {ECO:0000313|Proteomes:UP000002058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 1704 {ECO:0000313|Proteomes:UP000002058};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; CH476617; EEP80917.1; -; Genomic_DNA.
DR RefSeq; XP_002585070.1; XM_002585024.1.
DR AlphaFoldDB; C4JTH0; -.
DR STRING; 336963.C4JTH0; -.
DR GeneID; 8443016; -.
DR KEGG; ure:UREG_05759; -.
DR VEuPathDB; FungiDB:UREG_05759; -.
DR eggNOG; KOG0922; Eukaryota.
DR HOGENOM; CLU_001832_5_11_1; -.
DR InParanoid; C4JTH0; -.
DR OMA; FHEVMET; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000002058; Unassembled WGS sequence.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002058}.
FT DOMAIN 32..196
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 233..408
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 669 AA; 74322 MW; A0BC334AF895F79B CRC64;
MAADSDLSAG FVASRYKPPA LLPIARHRKS LLYVVENYPV TIVVGQTGSG KSTQLPQFLD
QAGWCADGKQ IAVTQPRRVA ATTVAARVAE EMRCNVGQEV GYSIRFEDVT SAATRVKFLT
DGLLLREALV DPLLSRYSVI MVDEAHERSL STDILLGVLK KVMKKRPELR IIVSSATLQA
KEFLQFFAGD QVDSGNSSDM GGKVGRIVSL EGRMYPVDSL FLENPTEDYV ERAVKTVFDI
HAEETSGDIL LFLTGREEID LAIQKISEYA ATLPPHSQGL QPLPLYAGLT TEQQLYVFEP
APENTRKVIV STNIAEASVT IEGIVYVIDC GYAKLRAYDP NTGIDTLTAV PISKASATQR
AGRAGRTKPG KCFRLYTEQS YESLPETSVP EIQRSNLAPV ILQLKALGID NIVRFDFFSA
PPAELVIRAL ELLYSLGALD DYAKLTKPLG MRMAELSVEP MMSKVLLNAS SFGCLSEMLS
IAAMTSLQGS VWYQQDDEKK ALESARRKFA AEEGDHLTYL NVYQAFVTKG KKDSRWCREN
SLNYKSMLKA VSNRAQLKRY LERFGIEVNE TLSSHRSQAS TTAEQIQRCL TTGYFAHAAR
MQPDGTFRTI SGGITLHAHP SSLMFNRKAD WVIFHEILQT ASKTFIRDVT KVEKSWLLEY
ASDYYRVKE
//
