ID C4KFL6_SULIK Unreviewed; 1000 AA.
AC C4KFL6;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=FAD linked oxidase domain protein {ECO:0000313|EMBL:ACR43350.1};
GN OrderedLocusNames=M164_2759 {ECO:0000313|EMBL:ACR43350.1};
OS Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Sulfolobus.
OX NCBI_TaxID=426118 {ECO:0000313|EMBL:ACR43350.1, ECO:0000313|Proteomes:UP000001479};
RN [1] {ECO:0000313|EMBL:ACR43350.1, ECO:0000313|Proteomes:UP000001479}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M.16.4 / Kamchatka #3 {ECO:0000313|Proteomes:UP000001479};
RX PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT "Biogeography of the Sulfolobus islandicus pan-genome.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP001402; ACR43350.1; -; Genomic_DNA.
DR RefSeq; WP_012736327.1; NC_012726.1.
DR AlphaFoldDB; C4KFL6; -.
DR GeneID; 84054263; -.
DR KEGG; sid:M164_2759; -.
DR HOGENOM; CLU_301816_0_0_2; -.
DR Proteomes; UP000001479; Chromosome.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProt.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR PANTHER; PTHR11748:SF119; D-2-HYDROXYGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13183; Fer4_8; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
FT DOMAIN 42..210
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT DOMAIN 506..536
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 1000 AA; 110980 MW; 98E8F5B04097B8E1 CRC64;
MSLEEELKSL LGDSFHDELV ERLSHSVDFG FVPELVWSGI KINIVPDYVA YPRSVEDIIN
VVRLGLKYKI PIVPYGRGTN RYGNAIPADG GILLDFSKMT NVTIDESNKM AIVEPGATWK
LVDIYAQQKG LQLRTFPSSY DSTVGGGIAG DALGIGSYEY GFISDNVSFV EMVNPKGDLV
RLEGKDLALV CGAEGTTGII AKAGLKLRNF SPTEAMIISF DNLDQMMHAV GEFYREVIPA
WHVQVRGPYI STYMAEKYKA PFEPQKWNMV ILYPSPRSPL VEPKIYKIAQ SYGGKVFEGE
WTGWWSFNHG VAAALRTQGL LIHQHGLIHY TRLLDLLKNL EKSIGKLGEL SPDGGFDVDI
ALERREVLLV NAFTQISVSP VDKKILYDLA KNTLMMDEFV KVNGSLLSIG IFAHKYAKNR
LSSMGKTFSD LGVDRYEVIR KYKEETDPNE IFNPGKLFDP KNRAKAILEI PRRQQEALNF
RFAIGFVKRL SPGGEVEGFR HVRRYLEDFA DYSLMCIDCS MCVTVCPQYR LIPQWPYAPK
GMFDFVRGAI AYYELNGSID IPDSVIAEIS GCHKCGLCDG VCPARIPIST LLIKLNSLVA
KKLPEEPTVE LSIFSDPELA SVNDPNSQFV LWVGKNAVSN PAVAITALKI LKKMGLKVKV
VGTSADSGFL DYISGNGNRF LEKIKQNLDT VNNSLEIITI TPEDYRTFST AYKDYSKLAG
AEVFFEVVPL ELRLLKSIVI DGSNENINLH VACFSSEYSD EVIKRLSEKG FRVKKIEGCS
GAILEKSLGK RADLMARAIG ERYGKVVTLC PLAAAKFRSV GINAVTLIEF LAEKLGIQSA
RYQVVSFQLD ENSKEYIKKE LIASILSSLN SQVNLIADTA SFSTSGVDEY KKIIEPIIVQ
VVDNIGKTIA SKLSGSIRQK SSESSIDKAI VLAEYVKEIS NTLSTIELDK VMQPFTSLLK
SRVTEEYDEN VVISAIIQLL RDNTEKLKTI IATEISKTLG
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