ID   C4L6G6_EXISA            Unreviewed;       692 AA.
AC   C4L6G6;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   SubName: Full=5'-Nucleotidase domain protein {ECO:0000313|EMBL:ACQ69997.1};
GN   OrderedLocusNames=EAT1b_1069 {ECO:0000313|EMBL:ACQ69997.1};
OS   Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b).
OC   Bacteria; Bacillota; Bacilli; Bacillales;
OC   Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX   NCBI_TaxID=360911 {ECO:0000313|EMBL:ACQ69997.1, ECO:0000313|Proteomes:UP000000716};
RN   [1] {ECO:0000313|EMBL:ACQ69997.1, ECO:0000313|Proteomes:UP000000716}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1283 / AT1b {ECO:0000313|Proteomes:UP000000716};
RX   PubMed=21460088; DOI=10.1128/JB.00303-11;
RA   Vishnivetskaya T.A., Lucas S., Copeland A., Lapidus A., Glavina Del Rio T.,
RA   Dalin E., Tice H., Bruce D.C., Goodwin L.A., Pitluck S., Saunders E.,
RA   Brettin T., Detter C., Han C., Larimer F., Land M.L., Hauser L.J.,
RA   Kyrpides N.C., Ovchinnikova G., Kathariou S., Ramaley R.F., Rodrigues D.F.,
RA   Hendrix C., Richardson P., Tiedje J.M.;
RT   "Complete genome sequence of the Thermophilic Bacterium Exiguobacterium sp.
RT   AT1b.";
RL   J. Bacteriol. 193:2880-2881(2011).
CC   -!- SIMILARITY: Belongs to the 5'-nucleotidase family.
CC       {ECO:0000256|RuleBase:RU362119}.
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DR   EMBL; CP001615; ACQ69997.1; -; Genomic_DNA.
DR   RefSeq; WP_012727116.1; NC_012673.1.
DR   AlphaFoldDB; C4L6G6; -.
DR   STRING; 360911.EAT1b_1069; -.
DR   KEGG; eat:EAT1b_1069; -.
DR   eggNOG; COG0737; Bacteria.
DR   HOGENOM; CLU_005854_7_3_9; -.
DR   OrthoDB; 9801679at2; -.
DR   Proteomes; UP000000716; Chromosome.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0008252; F:nucleotidase activity; IEA:UniProt.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0009166; P:nucleotide catabolic process; IEA:InterPro.
DR   Gene3D; 3.60.21.10; -; 1.
DR   Gene3D; 3.90.780.10; 5'-Nucleotidase, C-terminal domain; 1.
DR   InterPro; IPR008334; 5'-Nucleotdase_C.
DR   InterPro; IPR036907; 5'-Nucleotdase_C_sf.
DR   InterPro; IPR006146; 5'-Nucleotdase_CS.
DR   InterPro; IPR006179; 5_nucleotidase/apyrase.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR11575:SF24; 5'-NUCLEOTIDASE; 1.
DR   PANTHER; PTHR11575; 5'-NUCLEOTIDASE-RELATED; 1.
DR   Pfam; PF02872; 5_nucleotid_C; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR01607; APYRASEFAMLY.
DR   SUPFAM; SSF55816; 5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR   PROSITE; PS00785; 5_NUCLEOTIDASE_1; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362119};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362119}; Signal {ECO:0000256|RuleBase:RU362119}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|RuleBase:RU362119"
FT   CHAIN           27..692
FT                   /evidence="ECO:0000256|RuleBase:RU362119"
FT                   /id="PRO_5039764151"
FT   DOMAIN          179..397
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          496..647
FT                   /note="5'-Nucleotidase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02872"
SQ   SEQUENCE   692 AA;  75400 MW;  F48FD1B048795434 CRC64;
     MAKKSSRKLY TALAVAAVST ASLTPAAVTE AAPKASVVKA KSGYVYKGDL DAALDATYKG
     APIYWYKSSV DLEKLGTFQT ARGIVKGKGM YIEKRVRVLD HPLEILPPSE PLVFKQGKPA
     VGIVKQDVRF ASGTYEKPVR WSGINTDEVG EFVATATYTN RGKTITLEVP YKVEGYKLSI
     MHTNDTHAAL KYAPNRATAI KQVRAEKPDS LLIDAGDVFS GSLYFNEFKG QADLKLMNYM
     KYDLMVPGNH EFDLGTEQGH KELSDFVRYA NFPFVSSNVD YSKDQYMKNL YRNETTDKAY
     NGRLYEGVIK VVDGKKVGFF GLTTEETASI ASPGPIEFQN YIDEAQKAVD AFEEMGVDQI
     VAVSHLGFND NPAFDNDQLL AENVDGIDII VGGHTHTRLN QPVMVTEGKT EPTLIVQAYQ
     YSEFLGTLDV EFDKDGKIVK HAGSLIDVKA LQPDPYAVSL LAPFKEVVDG ISNDPIGVTL
     TAPLLNPRVD DEGNETGVSV RKNETALGNL ITDGMLTKAK EYDSAVIGAV QNGGGIRAKI
     DQGPITTGEV LTTLPFGNTL AIMDLKGSEL KAAFERSVGV YPLESGGFLH VSGFKVLFDS
     SKPAGERIVS LEYNNGSEFV AVDDATSYKV ATNFFTAQGG DNYAEFKKAF DEGRVNDLGL
     IDWENFRDHL ISLGEEVTPA VEGRIVDVNA AE
//