ID C4LPZ7_9INFB Unreviewed; 750 AA.
AC C4LPZ7;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 08-NOV-2023, entry version 49.
DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035, ECO:0000256|RuleBase:RU004330};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494, ECO:0000256|RuleBase:RU004330};
DE Flags: Fragment;
GN Name=PB1 {ECO:0000313|EMBL:ACR15686.1};
OS Influenza B virus (B/Taiwan/2643/2002).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Betainfluenzavirus;
OC Betainfluenzavirus influenzae; Influenza B virus.
OX NCBI_TaxID=521445 {ECO:0000313|EMBL:ACR15686.1};
RN [1] {ECO:0000313|EMBL:ACR15686.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Influenza B virus {ECO:0000313|EMBL:ACR15686.1};
RA Spiro D., Halpin R., Boyne A., Bera J., Ghedin E., Hostetler J.,
RA Fedorova N., Kim M., Zaborsky J., Overton L., Djuric K., Sarmiento M.,
RA Sitz J., Katzel D., Li W.C., Lin T.Y., Chang S.C., Huang C.G., Tsao K.C.,
RA Chen G.W., Shih S.R., Bao Y., Sanders R., Dernovoy D., Kiryutin B.,
RA Lipman D.J., Tatusova T.;
RT "The NIAID Influenza Genome Sequencing Project.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACR15686.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Influenza B virus {ECO:0000313|EMBL:ACR15686.1};
RG The NIAID Influenza Genome Sequencing Consortium;
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|RuleBase:RU004330};
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DR EMBL; CY040415; ACR15686.1; -; Viral_cRNA.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR Gene3D; 6.10.140.720; -; 1.
DR HAMAP; MF_04065; INFV_RDRP; 1.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR001407; RNA_pol_PB1_influenza.
DR Pfam; PF00602; Flu_PB1; 1.
DR PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU004330};
KW Transferase {ECO:0000256|ARBA:ARBA00022695};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 284..480
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACR15686.1"
SQ SEQUENCE 750 AA; 84036 MW; 0A785E654264CAE5 CRC64;
INPYFLFIDV PIQAAISTTF PYTGVPPYSH GTGTGYTIDT VIRTHEYSNK GKQYISDVTG
CTMVDPTNGP LPEDNEPSAY AQLDCVLEAL DRMDEEHPGL FQAASQNAME ALMVTTVDKL
TQGRQTFDWT VCRNQPAATA LNTTITSFRL NDLNGADKGG LVPFCQDIID SLDRPEMTFF
SVKNIKKKLP AKNRKGFLIK RIPMKVKDKI TKVEYIKRAL SLNTMTKDAE RGKLKRRAIA
TAGIQIRGFV LVVENLAKNI CENLEQSGLP VGGNEKKAKL SNAVAKMLSN CPPGGISMTV
TGDNTKWNEC LNPRIFLAMT ERITRDSPIW FRDFCSIAPV LFSNKIARLG KGFMITSKTK
RLKAQIPCPD LFSIPLERYN EETRAKLKKL KPFFNEEGTA SLSPGMMMGM FNMLSTVLGV
AALGIKNIGN KEYLWDGLQS SDDFALFVNA KDEETCMEGI NDFYRTCKLL GINMSKKKSY
CNETGMFEFT SMFYRDGFVS NFAMELPSFG VAGVNESADM AIGMTIIKNN MINNGMGPAT
AQTAIQLFIA DYRYTYKCHR GDSKVEGKRM KIIKELWENT KGRDGLLVAD GGPNIYNLRN
LHIPEIVLKY NLMDPEYKGR LLHPQNPFVG HLSIEGIKEA DITPAHGPVK KMDYDAVSGT
HSWRTKRNRS ILNTDQRNMI LEEQCYAKCC NLFEACFNSA SYRKPVGQHS MLEAMAHRLR
MDARLDYESG RMSKDDFEKA MAHLGEIGYI
//
