ID C4LQ41_9INFB Unreviewed; 748 AA.
AC C4LQ41;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 09-JUL-2014, sequence version 2.
DT 08-NOV-2023, entry version 50.
DE RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035, ECO:0000256|RuleBase:RU004330};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494, ECO:0000256|RuleBase:RU004330};
DE Flags: Fragment;
GN Name=PB1 {ECO:0000313|EMBL:ACR15730.2};
OS Influenza B virus (B/Harbin/7/1994).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Betainfluenzavirus;
OC Betainfluenzavirus influenzae; Influenza B virus.
OX NCBI_TaxID=587885 {ECO:0000313|EMBL:ACR15730.2};
RN [1] {ECO:0000313|EMBL:ACR15730.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B/Harbin/7/1994 {ECO:0000313|EMBL:ACR15730.2};
RA Spiro D., Halpin R., Bera J., Ghedin E., Hostetler J., Fedorova N.,
RA Hine E., Overton L., Djuric K., Sarmiento M., Sitz J., Katzel D.,
RA Couch R.B., Nino D., Jewell A.M., Bao Y., Sanders R., Dernovoy D.,
RA Kiryutin B., Lipman D.J., Tatusova T.;
RT "The NIAID Influenza Genome Sequencing Project.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACR15730.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B/Harbin/7/1994 {ECO:0000313|EMBL:ACR15730.2};
RG The NIAID Influenza Genome Sequencing Consortium;
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|RuleBase:RU004330};
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DR EMBL; CY040447; ACR15730.2; -; Viral_cRNA.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR Gene3D; 6.10.140.720; -; 1.
DR HAMAP; MF_04065; INFV_RDRP; 1.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR001407; RNA_pol_PB1_influenza.
DR Pfam; PF00602; Flu_PB1; 1.
DR PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000256|RuleBase:RU004330};
KW Transferase {ECO:0000256|ARBA:ARBA00022695};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 282..478
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACR15730.2"
SQ SEQUENCE 748 AA; 83799 MW; DE0C0E19B5F095F3 CRC64;
PYFLFIDVPI QAAISTTFPY TGVPPYSHGT GTGHTIDTVI RTHEYSNKGK QYVSDITGCT
MVDPTNGPLP EDNEPSAYAQ LDCVLEALDR MDEEHPGLFQ AASQNAMEAL MVTTVDKLTQ
GRQTFDWTVC RNQPAATALN TTITSFRLND LNGADKGGLV PFCQDIIDSL DKPEMTFFSV
KNIKKKLPAK NRKGFLIKRI PMKVKDRITR VEYIKRALSL NTMTKDAERG KLKRRAIATA
GIQIRGFVLV VENLAKNICE NLEQSGLPVG GNEKKAKLSN AVAKMLSNCP PGGISMTVTG
DNTKWNECLN PRIFLAMTER ITRDSPIWFR DFCSIAPVLF SNKIARLGKG FMITSKTKRL
KAQIPCPDLF SIPLERYNEE TRAKLKKLKP FFNEEGTASL SPGMMMGMFN MLSTVLGVAA
LGIKNIGNKE YLWDGLQSSD DFALFVNAKD EETCMEGIND FYRTCKLLGI NMSKKKSYCN
ETGMFEFTSM FYRDGFVSNF AMEIPSFGVA GVNESADMAI GMTIIKNNMI NNGMGPATAQ
TAIQLFIADY RYTYKCHRGD SKVEGKRMKI IKELWENTKG RDGLLVADGG PNIYNLRNLH
IPEIVLKYNL MDPEYKGRLL HPQNPFVGHL SIEGIKEADI TPAHGPVKKM DYDAVSGTHS
WRTKRNRSIL NTDQRNMILE EQCYAKCCNL FEACFNSASY RKPVGQHSML EAMAHRLRMD
ARLDYESGRM SKDDFEKAMA HLGEIGYT
//
