ID C4PCH0_GALSO Unreviewed; 843 AA.
AC C4PCH0;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Toll-like receptor 4 {ECO:0000256|ARBA:ARBA00040109};
OS Gallus sonneratii (Grey junglefowl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9033 {ECO:0000313|EMBL:ACR26300.1};
RN [1] {ECO:0000313|EMBL:ACR26300.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=530 {ECO:0000313|EMBL:ACR26300.1};
RX PubMed=20483729; DOI=10.4049/jimmunol.0903092;
RA Downing T., Lloyd A.T., O'Farrelly C., Bradley D.G.;
RT "The differential evolutionary dynamics of avian cytokine and TLR gene
RT classes.";
RL J. Immunol. 184:6993-7000(2010).
CC -!- SUBCELLULAR LOCATION: Cell projection, ruffle
CC {ECO:0000256|ARBA:ARBA00004466}. Early endosome
CC {ECO:0000256|ARBA:ARBA00004412}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; FJ915505; ACR26300.1; -; Genomic_DNA.
DR AlphaFoldDB; C4PCH0; -.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF521; TOLL-LIKE RECEPTOR 4; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 5.
DR SMART; SM00369; LRR_TYP; 8.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..843
FT /note="Toll-like receptor 4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011116866"
FT TRANSMEM 642..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 686..829
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 843 AA; 95668 MW; 040F6705C02434C3 CRC64;
MPSRAAPTAL TLGVLLQLLL VLSLLAGCIP SPCLEVIPST AFRCTGQNIS GVPAEIPNTT
LDLDLSFNSL KLLSSNYFSS VPELQFLDLS RCHIHTIEDN SFVDLYNLST LILTANSLQH
LGLAAFHGLT SLKKLVLVET SISSLSDLPI GHLNTLQELN LGHNNIASLK LPKYFANLTS
LRHLSFSSNN ITYISKGDLD ALRETNRLNL TLVLSLNNIK YIQSGSFAKI HLGELILRSS
FENLNAMHSS LQGLAGLQVN RLIVGEFTNI LKITAFQNGL LSGLCQVQMQ EFVLMCFREF
DNDTDTLFDC IGNVTTIRLV DLNLETLSEV PMFSQVKHLE WKKCKFQELP AEKLSLFKEL
RVLRITKSKD LNGFEQKFGS LTYLEVVDLS ENRLSFLTCC SPKFPRSPNL KHLNLSFNSD
ISLTGEFANL RNLLYLDLQH TKLIHHGTYP VFLLLQKLIY LDISYTKTHV MSHLIFHGLN
SLQVLKMAGN SFENNTLTNN FENVRRLRIL DISSCKLVWV DQSTFNSLSE LKELIISNNK
LLTFDPVTYK PLQALTALDF SNNQMSFLSD SALEILPDSL VLLDISHNLF ECSCTHLNFL
KWVKEKQDLL RNKHSMICHT PAYMKNMSLS NFDMSSCHPN PTTVACSVTV LLAAGVFLFL
IYKFYFQLYY SLVLLSGCKH SAERGDIYDA FVIHSSKDQE WVMKELVEPL EEGKPPFQLC
LYFRDFLPGV PIVTNIIQEG FLSSRNVIAV ISADFLESKW CSFEFDIARS WQLVEGKAGI
IMIILGEVDK TLLRQRLGLS RYLRRNTYLE WKNKEISRHI FWRQLTSVLL EGKKWNHEEI
KLM
//
