ID C4QV11_KOMPG Unreviewed; 237 AA.
AC C4QV11;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=N-(5'-phosphoribosyl)anthranilate isomerase {ECO:0000256|ARBA:ARBA00022272};
DE EC=5.3.1.24 {ECO:0000256|ARBA:ARBA00012572};
GN OrderedLocusNames=PAS_chr1-3_0029 {ECO:0000313|EMBL:CAY67081.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY67081.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY67081.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC tryptophan from chorismate: step 3/5. {ECO:0000256|ARBA:ARBA00004664}.
CC -!- SIMILARITY: Belongs to the TrpF family.
CC {ECO:0000256|ARBA:ARBA00007571}.
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DR EMBL; FN392319; CAY67081.1; -; Genomic_DNA.
DR RefSeq; XP_002489365.1; XM_002489320.1.
DR AlphaFoldDB; C4QV11; -.
DR SMR; C4QV11; -.
DR STRING; 644223.C4QV11; -.
DR EnsemblFungi; CAY67081; CAY67081; PAS_chr1-3_0029.
DR GeneID; 8197962; -.
DR KEGG; ppa:PAS_chr1-3_0029; -.
DR eggNOG; KOG4202; Eukaryota.
DR HOGENOM; CLU_076364_1_0_1; -.
DR InParanoid; C4QV11; -.
DR OMA; FHGDESP; -.
DR OrthoDB; 2054501at2759; -.
DR UniPathway; UPA00035; UER00042.
DR Proteomes; UP000000314; Chromosome 1.
DR GO; GO:0004640; F:phosphoribosylanthranilate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00405; PRAI; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR HAMAP; MF_00135; PRAI; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR001240; PRAI_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR InterPro; IPR044643; TrpF_fam.
DR PANTHER; PTHR42894; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR PANTHER; PTHR42894:SF1; N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE; 1.
DR Pfam; PF00697; PRAI; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:CAY67081.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 78..234
FT /note="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)"
FT /evidence="ECO:0000259|Pfam:PF00697"
SQ SEQUENCE 237 AA; 26191 MW; 448F7A14BDD08570 CRC64;
MALVKICGLQ SLEAAETAVN NGASLVGVIM VPGRERTVKQ EVAREISQMV REKRISKGSK
YLDSRQLRKE WDDCPLEDWF EYNVKEINSS GPFLVGVFRN QSIDEIQQAI HTHGLDFVQL
HGSEDFDSYI RNIPVPVITR YTDNAVDGLT GEDLAINRAL VLLDSEQGGE GKTIDWARAQ
KFGERRGKYL LAGGLTPDNV AHARSHTGCI GVDVSGGVET NASKDMDKIT QFIRNAT
//
