ID C4R1I3_KOMPG Unreviewed; 1233 AA.
AC C4R1I3;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=RNA helicase {ECO:0000313|EMBL:CAY69357.1};
GN OrderedLocusNames=PAS_chr2-1_0709 {ECO:0000313|EMBL:CAY69357.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY69357.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY69357.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
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DR EMBL; FN392320; CAY69357.1; -; Genomic_DNA.
DR RefSeq; XP_002491637.1; XM_002491592.1.
DR AlphaFoldDB; C4R1I3; -.
DR SMR; C4R1I3; -.
DR STRING; 644223.C4R1I3; -.
DR EnsemblFungi; CAY69357; CAY69357; PAS_chr2-1_0709.
DR GeneID; 8198327; -.
DR KEGG; ppa:PAS_chr2-1_0709; -.
DR eggNOG; KOG0947; Eukaryota.
DR HOGENOM; CLU_002902_1_4_1; -.
DR InParanoid; C4R1I3; -.
DR OMA; CGSDITR; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:EnsemblFungi.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.30.30.1160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR048727; Ski2_beta-barrel.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF21409; Ski2_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CAY69357.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 296..454
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 561..757
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 502..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1233 AA; 140305 MW; 5ADC6A3638B7C37D CRC64;
MREIDDILQE IHDLSLNKVD LPPDTQTKFQ FPSVTEEEEI NDLKKQYLTP SDQIPPDLLK
EFLIIPDESD QKLKFYQALV KIPPFMDRTK IKFKRKGIEG KIVGYEEALD LSGDNLTSSN
SFSLHRKPAE NGSSIRGQTT NLPFLPGGLV SKAVKDTESI NNLLHRDDQG LFDIPLGFER
GLQLEKAGDT ELVDELSKLP ESNEETLENQ IPSGDVELLD PETLEEDAIQ EGDEIDALLP
SDISFSKRPK TERPQAARQW AHLVDLDHKL ENFHELVPNM ARTWPFELDT FQQEAIYHLE
KGDSVFVAAH TSAGKTVVAE YVIAMANINM TKAIYTSPIK ALSNQKFRDF KHDFEDIDVG
LITGDVQINQ EANCLIMTTE ILRSMLYRGA DVIRDVEFVI FDEVHYVNDI DRGVVWEEVI
IMLPEHVKIV MLSATVPNTM EFASWVGRTK QKDVYVISTP KRPIPLEIFV WAKSDLFKVV
DSNRNFLEKN FQAHSDVLVK PKKEVTGSQA GNRGGRGNAR GASRGGRGSS STVSSRGRGG
SANVGTRFTK RDGPNKKTWT NLVQYLRSHD LLPSVIFVFS KARCEEYADS LQGVNFCTGS
ERSRIHMFID KAVSRLKKED RELPQIMKMR EMLSRGIAVH HGGLLPIMKE VIEILFAKTL
IKVLFATETF AMGLNLPTRT VVFSELRKHD GTGFRNLLPG EFTQMSGRAG RRGLDTTGTV
IVMSYNEPLE SKPFQQITLG VPTKLVSQFR LTYNMILNLL RIEALRVEEM IKRSFSENTT
QSGLKENEKE IIELQKKIAE ISQAGCQECD PAKLKEFSTA ICDYTKLTGE LIRLSLEIPL
HRKRFRRGML FIYTDADGFP APAFLYDIKM SDSLFVALVF DIERCEENNT GLPYIPESPS
FIKNTIPKWK FKGNFRFTTI PFNKVQYVTR FVLQVLLKSI IRMEPESIEK AEEQILQLLH
FYKKFEEYNW SASLTIPQND LYKKIQDYRK IIANAPVIQC PSLREHYIQI KDLDSLRSRL
ITLKSLVSDD NMTLLPDYEQ RLKVLNELEF VDDHLNVVLK GRIACEINSG WELALTELLL
DNFLADFDPE EIVALLSAFV YEGRTRDDEE PALTPRLEKG KAKIRDIVSH LLEIFQDKQV
SLSAEEESFL EAKRFNLVNV VYEWAKGTSF SDIMKLSSEA EGTIVRVITR LDEVCREVKS
AALIIGDSAL HDKMSEAQEK IKRDIVFCAS LYL
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