ID C4R2G0_KOMPG Unreviewed; 1118 AA.
AC C4R2G0;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Haploid specific endoprotease {ECO:0000313|EMBL:CAY69684.1};
GN OrderedLocusNames=PAS_chr2-2_0232 {ECO:0000313|EMBL:CAY69684.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY69684.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY69684.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FN392320; CAY69684.1; -; Genomic_DNA.
DR RefSeq; XP_002491964.1; XM_002491919.1.
DR AlphaFoldDB; C4R2G0; -.
DR SMR; C4R2G0; -.
DR STRING; 644223.C4R2G0; -.
DR EnsemblFungi; CAY69684; CAY69684; PAS_chr2-2_0232.
DR GeneID; 8198639; -.
DR KEGG; ppa:PAS_chr2-2_0232; -.
DR eggNOG; KOG0959; Eukaryota.
DR HOGENOM; CLU_008088_0_0_1; -.
DR InParanoid; C4R2G0; -.
DR OMA; TGSHNDP; -.
DR OrthoDB; 2046703at2759; -.
DR Proteomes; UP000000314; Chromosome 2.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 38..160
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 208..386
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 457..726
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
SQ SEQUENCE 1118 AA; 128185 MW; 07C4BC84BD228495 CRC64;
MSLKVQEKVH CYDTLFYIPE SCSHRGHRLI QLRNGLIVLL VSDPLKDVSA CSLTVATGAH
DDPCDLPGLA HLCEHMLLLG TKKYPQPDHF YKLISKLGGT QNATTTGETT SFYFETPSGV
TNDGIPIIDH VLDVFSQFFK EPLFNKSNSN REIMAVNNEH TNNKTINQRL MYHGLRLLSS
RNHPFHRFAT GNISTLLNTP KARRINVRER LLKFHAKNYK AANMSLVLKG PQSLNALQKL
VMTHFIEGIP GQEFPNGFSL TNLHINQRKW NYKHPAFERT SQCDVTLINR SIDKPWCRLH
FPVGDDHLLS VFWVHIYGDE SPNSICDMLK QENLITSLTA YPLTISVGEV LLTLEMKLTT
NGAKKISQIL NILFSFTEEL IKTDLKDYLR SIISLELFNY LNSEGQGSSM DEVHSLSLGL
LNNFARLGPN WIIRQQSGWN SLYEEHETNT IDYFFHELLR RVKFNNCKLI FIGKEIHFKY
FKLLNIKFNR PRTDPYFDFE YCLGSSLTAP AMDIPLAVSF PTLNTFLPAE FHDPMNVLKR
IRNASINAYK SPLSLVAKAE GVEDPIPTQI ENNHFHQLWF RKTNNERNGI VSVDMVQDII
PCSSTATIFI DIICELLAGL LKKKLYEAEL LGVTWTIYPS VKGDCSIGLT VSGFSETLSE
MFKAIIDQIQ CLLANLSTFK DEYIDARVAV RTRYESLKDQ NSIMLATAGL IHVIEENTWT
IDERLEKLEE ITKDELKNFL GTFFGSPCSV SMLYEGMTDF SMTYSQLLNP LTKHRDCFGD
PSVSFRCFRR SYLLNTGNYA YYKTSNDATS AISYFVQTGL RSDVYNRTLT KVVSFLMSLH
LEPKLRTEEQ LGYIVMGSIK LFRATTGICI SVMSSEFEVE YLHFRIKCFL EYLYDVTNRM
TQDEFKVQIL NPMLTKIQND TSSSKLDSSS AIMKMNIQGI TGVNEPNTLA LISHKSCWEQ
ISSGTYNFCS YSFDDFIDTY RLEMLDKCEF VEWFRSKFLE KEQQLSIMIK SKFNKEQLKM
EMLTLRLSAF LNVAGLRITD EDLEHILKKS NGEFGALIKL LVKHFKSRSL KLTGFVVHEM
MTTVAYSLNK NSKYQRMLAK RIDNMDNFHS SLHCIDYD
//