ID C4R4D0_KOMPG Unreviewed; 302 AA.
AC C4R4D0;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Vacuolar Fe2+/Mn2+ transporter {ECO:0000313|EMBL:CAY70416.1};
GN OrderedLocusNames=PAS_chr3_0372 {ECO:0000313|EMBL:CAY70416.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70416.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70416.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CCC1 family.
CC {ECO:0000256|ARBA:ARBA00007049}.
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DR EMBL; FN392321; CAY70416.1; -; Genomic_DNA.
DR RefSeq; XP_002492595.1; XM_002492550.1.
DR AlphaFoldDB; C4R4D0; -.
DR STRING; 644223.C4R4D0; -.
DR EnsemblFungi; CAY70416; CAY70416; PAS_chr3_0372.
DR GeneID; 8199505; -.
DR KEGG; ppa:PAS_chr3_0372; -.
DR eggNOG; KOG4473; Eukaryota.
DR HOGENOM; CLU_038957_0_0_1; -.
DR InParanoid; C4R4D0; -.
DR OMA; HESEPAI; -.
DR OrthoDB; 1357at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IEA:InterPro.
DR CDD; cd02435; CCC1; 1.
DR InterPro; IPR008217; Ccc1_fam.
DR PANTHER; PTHR31851; FE(2+)/MN(2+) TRANSPORTER PCL1; 1.
DR PANTHER; PTHR31851:SF52; PROTEIN CCC1; 1.
DR Pfam; PF01988; VIT1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 302 AA; 32561 MW; A86E7278839D1132 CRC64;
MAVVTLKNAI LSLFPANTSD SQNEPLLGED STGNAGYAAR DVQGLESEIE SNSTKTQNIS
EDNQNQTVLW GLFEKVDPRV MSDIIIGLSD GLTVPFALTA GLSSLGDSKL VITGGMAELV
SGSISMGLGG FLAARSESEF YKSQVRKEKQ LFFNNKELLE EELEDIFLDI GMSETTTESA
IRDLSKSPKA MIDFIIRHGK GLEEPADGRQ VTSALTIGLS YFLGGFVPLV PYFFTAIVQT
GLIISVLVMG VTLFWFGYLK TAISMGEDCS LWMRVSEGLQ MVLIGSIAAG SAWGLVRVID
TN
//
