ID C4R584_KOMPG Unreviewed; 829 AA.
AC C4R584;
DT 07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN OrderedLocusNames=PAS_chr3_0672 {ECO:0000313|EMBL:CAY70720.1};
OS Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Komagataella.
OX NCBI_TaxID=644223 {ECO:0000313|EMBL:CAY70720.1, ECO:0000313|Proteomes:UP000000314};
RN [1] {ECO:0000313|EMBL:CAY70720.1, ECO:0000313|Proteomes:UP000000314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS115 / ATCC 20864 {ECO:0000313|Proteomes:UP000000314};
RX PubMed=19465926; DOI=10.1038/nbt.1544;
RA De Schutter K., Lin Y.C., Tiels P., Van Hecke A., Glinka S.,
RA Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT "Genome sequence of the recombinant protein production host Pichia
RT pastoris.";
RL Nat. Biotechnol. 27:561-566(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; FN392321; CAY70720.1; -; Genomic_DNA.
DR RefSeq; XP_002492899.1; XM_002492854.1.
DR AlphaFoldDB; C4R584; -.
DR SMR; C4R584; -.
DR STRING; 644223.C4R584; -.
DR EnsemblFungi; CAY70720; CAY70720; PAS_chr3_0672.
DR GeneID; 8200372; -.
DR KEGG; ppa:PAS_chr3_0672; -.
DR eggNOG; KOG0922; Eukaryota.
DR HOGENOM; CLU_001832_5_10_1; -.
DR InParanoid; C4R584; -.
DR OMA; KVKVWRH; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000000314; Chromosome 3.
DR GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:EnsemblFungi.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR CDD; cd17917; DEXHc_RHA-like; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:CAY70720.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000314}.
FT DOMAIN 189..353
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 367..550
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 93439 MW; E443D7467115A283 CRC64;
MSVDETLNGS QPVDINQIVE NGDKKKSKRK KKSKSRENDS AIVVNEPTSV VKTTVLQNKK
IKFDKLEEIE VAPQPEIASD KDSANGNNPN FIQSSTIETV EERIIERERP ILRSSPQVLQ
KKGKELPKNP KVIEFYSDNE DEDDFDFKGL AFDKSSFSKE NIRKIKQKAE ELLEIRKTLP
VFKAKDELIP TLLKNKVNIL IGETGSGKST QIPQFLMPLN SKGIAVTQPR RVAAINLATR
VSQEHGCVLG THVGFSVRFN NATRNDTKLK YLTDGMLLRE LMIDPLLSRY STIIIDEAHE
RTILTDLLMG FLKSLVTVER KDDPDFRVII MSATLDAEKF SKFFADAPIL FVEGKMYPVE
RSYVKAPVDD IVDTVVKTLV HLNQGEQKGD VLCFLPGQEE IDKAEAVLNQ LAPLLPKEAP
RIVPLPLYAA LPSAKQAKVF LPVKNHQRKL ILATNIAETS VTVPGIKYVV DSGLRKVKVW
RHQLGLSTLL TTPISKASAT QRSGRAGRES EGKCFRLYTE SDYFKLIEQT EPEIVRSDII
SPVLMLKRLQ VDDILNWHWL ENPGQEALIA ALQQLYSLQA IDEAGKITDL GEKMTVLPLA
PHLSSVLITG HENGCLEPVI DIVSCLSVDN LILNPASDRR DEVNERRRAV CNLGNRYGDL
MMMKELFDMY LDMPDSSERK RWCKELDLSF KGFKNVLRVR EQLRQYMNNL YSKEGASILA
QESEEYDEEL GITTSNKPMD VDSILKSFLK GFINNTAIGM PDRSYRTVTT GQLIAIHPSS
MVFGKKLDAI MYIEYVYTTR GYARNVSSVQ LEWLQEVAPH LLGTRTSIN
//
