ID C4Y5U1_CLAL4 Unreviewed; 309 AA.
AC C4Y5U1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 22-FEB-2023, entry version 42.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EEQ39397.1};
GN ORFNames=CLUG_03525 {ECO:0000313|EMBL:EEQ39397.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ39397.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ39397.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ39397.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the INSIG family.
CC {ECO:0000256|ARBA:ARBA00007475}.
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DR EMBL; CH408079; EEQ39397.1; -; Genomic_DNA.
DR RefSeq; XP_002616284.1; XM_002616238.1.
DR AlphaFoldDB; C4Y5U1; -.
DR STRING; 306902.C4Y5U1; -.
DR GeneID; 8496619; -.
DR KEGG; clu:CLUG_03525; -.
DR VEuPathDB; FungiDB:CLUG_03525; -.
DR HOGENOM; CLU_088332_0_0_1; -.
DR InParanoid; C4Y5U1; -.
DR OMA; IEWSSFL; -.
DR OrthoDB; 1982254at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR025929; INSIG_fam.
DR PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1.
DR PANTHER; PTHR15301:SF3; PROTEIN NSG1-RELATED; 1.
DR Pfam; PF07281; INSIG; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007703};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 235..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 34395 MW; 0B0CB8CA5B5EB7A8 CRC64;
MAKTKGKSSL QAFEEQERVM EKSDSVVNLT KPSLYGIYND SSTSLNKENE EVEEYLEGNQ
LHIKAKDSSK RPRNQGTVKT SHQKVSSPQR IASILFRVAT VSTAALVYNE VTKHIHASNL
NDIGTQINAY LVTFMENWKP IRYLANVDHP ADAFFSLASE GLILSSILPL LDNVMPGSFS
KRLLSSSPDP YYRSNLMNDI VRSSIAFLGV SYAIRHIEWK SSLQMAMTWS LINPCLWLLL
DGTISGFIAS TGTAFGGSAI VYYQNGVKFS TDKDTDLIIL LFIASFFFCG VIIFGKLGRL
LFGKSKFQN
//
