ID C4Y5Z8_CLAL4 Unreviewed; 469 AA.
AC C4Y5Z8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Calcineurin-like phosphoesterase domain-containing protein {ECO:0000259|Pfam:PF00149};
GN ORFNames=CLUG_03582 {ECO:0000313|EMBL:EEQ39454.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ39454.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ39454.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ39454.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CH408079; EEQ39454.1; -; Genomic_DNA.
DR RefSeq; XP_002616341.1; XM_002616295.1.
DR AlphaFoldDB; C4Y5Z8; -.
DR GeneID; 8496803; -.
DR KEGG; clu:CLUG_03582; -.
DR VEuPathDB; FungiDB:CLUG_03582; -.
DR HOGENOM; CLU_011607_0_0_1; -.
DR InParanoid; C4Y5Z8; -.
DR OMA; LHCMKYP; -.
DR OrthoDB; 54839at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR033308; PGAP5/Cdc1/Ted1.
DR PANTHER; PTHR13315; METALLO PHOSPHOESTERASE RELATED; 1.
DR PANTHER; PTHR13315:SF4; METALLOPHOSPHOESTERASE, ISOFORM E; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007703};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 389..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..318
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
SQ SEQUENCE 469 AA; 55193 MW; 5C286DDC4E72A03B CRC64;
MFMNFRRREK RNAGAKEIAA SSRIERKNTV PLAKSSDTHY GARLWVPLLL LWFMVIHYFE
RVRVKSAMDA CQWENWENWP EQRAHIKPHR VVFIADPQLV DDHTYPKLPR ALNYLIRKMS
DNYLYINHKF MQAYLDPDTT IFVGDLFDGG REWDDNAWLE EYERFNRIFP QKTNRRSYRS
LPGNHDIGFQ NISLHNQRRF TAFFGEANDY FELGNHTFIQ IDTISLSHED PEVNREATEF
LSTVGQKLLP EMPRIVLTHV PLYRDPNVEL CGPGRESKRP FPLQRGFQYQ TVIDYKYSEQ
ILKNLRPILV FSGDDHDYCD IVHVDYSDNS KKLAREISCK TPSMTNGINY PAYQLLSLNN
PYDKHSTTSN DLKTYETMMC YLPNPYRGVK VYGILLVISF ALFYLCITHP KSVQDFIESI
YPSQLLPQAS QVYQKHTNSV ERRRILAFVR SCVLLFAYVS LLLALYNRM
//
