ID C4Y8Q8_CLAL4 Unreviewed; 322 AA.
AC C4Y8Q8;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 22-FEB-2023, entry version 63.
DE RecName: Full=Protein URE2 {ECO:0000256|PIRNR:PIRNR037861};
GN ORFNames=CLUG_04586 {ECO:0000313|EMBL:EEQ40458.1};
OS Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Metschnikowiaceae; Clavispora.
OX NCBI_TaxID=306902 {ECO:0000313|EMBL:EEQ40458.1, ECO:0000313|Proteomes:UP000007703};
RN [1] {ECO:0000313|EMBL:EEQ40458.1, ECO:0000313|Proteomes:UP000007703}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42720 {ECO:0000313|EMBL:EEQ40458.1,
RC ECO:0000313|Proteomes:UP000007703};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Plays an important role in the cellular response to the
CC nitrogen source. {ECO:0000256|PIRNR:PIRNR037861}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR037861}.
CC -!- SIMILARITY: Belongs to the GST superfamily.
CC {ECO:0000256|ARBA:ARBA00007409, ECO:0000256|PIRNR:PIRNR037861}.
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DR EMBL; CH408080; EEQ40458.1; -; Genomic_DNA.
DR RefSeq; XP_002615704.1; XM_002615658.1.
DR AlphaFoldDB; C4Y8Q8; -.
DR STRING; 306902.C4Y8Q8; -.
DR GeneID; 8496144; -.
DR KEGG; clu:CLUG_04586; -.
DR VEuPathDB; FungiDB:CLUG_04586; -.
DR HOGENOM; CLU_011226_14_1_1; -.
DR InParanoid; C4Y8Q8; -.
DR OMA; KFFQNQP; -.
DR OrthoDB; 1404190at2759; -.
DR Proteomes; UP000007703; Unassembled WGS sequence.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR GO; GO:0006808; P:regulation of nitrogen utilization; IEA:InterPro.
DR CDD; cd10293; GST_C_Ure2p; 1.
DR CDD; cd03048; GST_N_Ure2p_like; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR017298; Ure2.
DR PANTHER; PTHR44051; GLUTATHIONE S-TRANSFERASE-RELATED; 1.
DR PANTHER; PTHR44051:SF3; TRANSCRIPTIONAL REGULATOR URE2; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF02798; GST_N; 1.
DR PIRSF; PIRSF037861; Prion_URE2; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SFLD; SFLDG00358; Main_(cytGST); 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 3: Inferred from homology;
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063,
KW ECO:0000256|PIRNR:PIRNR037861};
KW Reference proteome {ECO:0000313|Proteomes:UP000007703}.
FT DOMAIN 80..164
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 173..322
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 322 AA; 35810 MW; F9557748BD07F320 CRC64;
MNGMQNAGDT DSGSGNQQTG NGGGGAISNL SAGLKSVSLS DQQQNAVNLN LLQQQLHNEA
ADNVATQTRI SRFFANQPTE GYTLFSHRSA PNGFKVAIIL SELNLPFNTI FLDFNSGEQR
APEFVSINPN ARVPALIDHT NDNTSIWESG AIILYLVSKH LKEHGECALW SDNIVEQSQI
SSWLFFQTSG HAPMIGQALH FRYFHSCPVP SAVERYTDEV RRVYGVIEMA LAERREALIM
DFDRDNAAAY SAGTTPLSSS RYFDYPVWLV GDRATVADLS FVPWNNVVDR IGINLKVEFP
EVYKWTKYMM RRPAVIRALR GD
//
