ID C4YKZ1_CANAW Unreviewed; 799 AA.
AC C4YKZ1;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=CAWG_01504 {ECO:0000313|EMBL:EEQ43272.1};
OS Candida albicans (strain WO-1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294748 {ECO:0000313|EMBL:EEQ43272.1, ECO:0000313|Proteomes:UP000001429};
RN [1] {ECO:0000313|EMBL:EEQ43272.1, ECO:0000313|Proteomes:UP000001429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-1 {ECO:0000313|EMBL:EEQ43272.1,
RC ECO:0000313|Proteomes:UP000001429};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
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DR EMBL; CM000309; EEQ43272.1; -; Genomic_DNA.
DR AlphaFoldDB; C4YKZ1; -.
DR PaxDb; 5476-C4YKZ1; -.
DR VEuPathDB; FungiDB:CAWG_01504; -.
DR HOGENOM; CLU_014892_2_1_1; -.
DR OMA; CEVLYIC; -.
DR Proteomes; UP000001429; Chromosome R.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF102; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51726; MYST_HAT; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 240..542
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 189..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..205
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..755
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 424
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 799 AA; 92031 MW; 7247B58CE59BDF41 CRC64;
MVSHLLNQLK ITNNHIYSNI VPQDLDKRTI RAKPTNDYSL KSMIKNNTHQ KSTIPITNTT
KIKSVHDDSN SNIKRVKRSF KHNNIFVKLT KKKCIVVINY DKTKLSTITR SKLDTVPLLP
NSTSFISENQ NQNQVDTSIL SEIQLPYKGI LKYPDCIIND TDPTKLDTER FNKYLDEGIK
LRNKTTCHLE TETETETETE TKTEIETESQ SQVFSNLLHP ILNESNQSTE STPVPNYSNL
NKSKINRIVL RDFEINTWYI APYPEEYSQC EVLYICEYCL KYMNSPMSYR RHQLKNCNFS
NNHPPGLEIY RDQKSKISIW EVDGRKNINY CQNLCLLAKL FLNSKTLYYD VEPFIFYVLT
EIDEKNPSNY HFVGYFSKEK LNSSDYNVSC ILTLPIYQRK GYGNLLIDFS YLLSRNEFKY
GTPEKPLSDL GLLSYRNYWK VTIAYKLKQI YDKYFSCNAN GDGDSVSDNA RLSLSIDTLC
KLTGMIPSDV IVGLEQLDSL ARNPITHNYA IVINLDKINT EIAKWEKKSY TKLVYEKLLW
KPMLFGPSGG INSAPSIQPP QPQSTLVTTT TMSTREGTTN SHPKPVIPQN SISLITNFLK
DDINNPYTFE EEGFKEIEAH RETKNEEIKN ASLVEYVTCY PGIVVNNHFV NGGGGGSGES
NGSNDQIKGH KKMLKKRKRI IDDDDDDDDE IEKIFEIDEI PSNDENEPDF EDDSDDVDDF
MDDDEEEVVE IKDNDSDEDV SEDIIEILDD DDQEEEDWRR TWKRRVPSPP KRKTVNVLTG
NNNKPRGRGR PRGTFKLKA
//
