ID C4YL19_CANAW Unreviewed; 1018 AA.
AC C4YL19;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Ribosome quality control complex subunit 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAWG_01533 {ECO:0000313|EMBL:EEQ43300.1};
OS Candida albicans (strain WO-1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294748 {ECO:0000313|EMBL:EEQ43300.1, ECO:0000313|Proteomes:UP000001429};
RN [1] {ECO:0000313|EMBL:EEQ43300.1, ECO:0000313|Proteomes:UP000001429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-1 {ECO:0000313|EMBL:EEQ43300.1,
RC ECO:0000313|Proteomes:UP000001429};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR EMBL; CM000309; EEQ43300.1; -; Genomic_DNA.
DR AlphaFoldDB; C4YL19; -.
DR PaxDb; 5476-C4YL19; -.
DR VEuPathDB; FungiDB:CAWG_01533; -.
DR HOGENOM; CLU_003612_1_1_1; -.
DR OMA; MFLEFFA; -.
DR Proteomes; UP000001429; Chromosome R.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 567..676
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 889..990
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 439..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 738..800
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 993..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 330..357
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 825..866
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 454..468
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..773
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1018 AA; 116561 MW; 7918789DF0F9EC23 CRC64;
MKQRITGLDL QILTSELSKE LSNYRLQNIY NVASNSRQYL FKFSIPDSKK VVVLEYGNRI
HLTDFERPTT QQPTNFVTKL RKHLKTRRLS GIKQISNDRI LVLEFSDGKY YLVLEFFSAG
NILLLDESQR ILALQRLVSA KQENDRYAVN EEYKMFDKSL FQQDFHYEKR SYDLDEVESW
IQTHKLKLSQ NSDNKKAKVF SIHKLAFINA SHLSGELIQK CFFESGIDPS QSCLSFEKNQ
GALQRVVNAL GVCEDKYIDL INGAIATEGY IVAKKNNKVS EKSDLEYIYD EFHPFEPYKP
NQEGIKFISV SGYNKTLDKF FSNIESTKFS IKIEQQKENA AKRLEKARSE RDKQIDSLVA
QQRLNAKKGE LIQYHSELVE ECRSYVQSFI DQQMDWTNIE TVISLEQKKK NELAQHIQLP
LNLKENKIKV LLEDFDDYEE STESASATET GSETETESES ESSSESESDN DEDKIPVKRT
QRKTNTKEKP KRKTIPTWID LSQSAFANAR SYFDSKKTAE TKQVKVENST SMALKNAERK
ITQDLTRSLK QENDTLKEIR PKYWFEKFFW FVSSEGYLCL AGKDASQTDM IYYRHFSDND
SIVSADMEGS LKVFIKNPLK GEALPPSTLM QAGIFAMSAS SAWNGKVTTS AWVLHGTEIS
KRDFDGSIVP EGEFNYLVQK EYLPPAQLVM GFGFYCLLDD ESTKRYGEIR TKRELEHGFA
IVVDNKKKEL EEIRLAQKAS AKENTAQEQR VDESSESDDN EDDGGEDADS PDTDTVSVDA
NGEEKPVIVQ QLPRGKRSKL KKIAAKYRDQ DEEERKLRMD ALGTLKQVEE RLSKTQIENS
EKSESVKKQQ QKEVILERKK KQKERELQKY LLGDDNNDEE TNNESHIVNY LEILDSFTAK
PSTKDTIVGL VPVFAPWSAL QKFKYKVKIQ PGSGKKGKCI GDSINYFVNR KMDSSSSDVD
LDWPQEREFI NNFKTNDIVG IFTVGKVKLV LPGGSGDSNK SGKSNNKKPA SKKGNKKK
//
