ID C4YLK6_CANAW Unreviewed; 941 AA.
AC C4YLK6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 08-NOV-2023, entry version 39.
DE RecName: Full=Hyphally-regulated cell wall protein N-terminal domain-containing protein {ECO:0000259|Pfam:PF11765};
GN ORFNames=CAWG_01724 {ECO:0000313|EMBL:EEQ43487.1};
OS Candida albicans (strain WO-1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294748 {ECO:0000313|EMBL:EEQ43487.1, ECO:0000313|Proteomes:UP000001429};
RN [1] {ECO:0000313|EMBL:EEQ43487.1, ECO:0000313|Proteomes:UP000001429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-1 {ECO:0000313|EMBL:EEQ43487.1,
RC ECO:0000313|Proteomes:UP000001429};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: GPI-anchored cell wall protein involved in cell wall
CC organization, hyphal growth, as well as in host-fungal interaction and
CC virulence. {ECO:0000256|ARBA:ARBA00003560}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004589}; Lipid-
CC anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004589}. Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004191}.
CC -!- SIMILARITY: Belongs to the HYR1/IFF family.
CC {ECO:0000256|ARBA:ARBA00009873}.
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DR EMBL; CM000309; EEQ43487.1; -; Genomic_DNA.
DR AlphaFoldDB; C4YLK6; -.
DR PaxDb; 5476-C4YLK6; -.
DR VEuPathDB; FungiDB:CAWG_01724; -.
DR HOGENOM; CLU_006199_1_0_1; -.
DR OMA; CEVLTIY; -.
DR Proteomes; UP000001429; Chromosome R.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0009277; C:fungal-type cell wall; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR031573; Cell_wall_rpt.
DR InterPro; IPR021031; Hyphal-reg_cell_wall_N.
DR Pfam; PF11765; Hyphal_reg_CWP; 1.
DR Pfam; PF15789; Hyr1; 3.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Secreted {ECO:0000256|ARBA:ARBA00022512}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..941
FT /note="Hyphally-regulated cell wall protein N-terminal
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002946608"
FT DOMAIN 12..339
FT /note="Hyphally-regulated cell wall protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11765"
SQ SEQUENCE 941 AA; 98816 MW; A68C67D5BDD6AA96 CRC64;
MQLFQNIFVS IALLTQIVFA IEITENKVDR GTVTLNLGDI TIYPGASWSI IDNAYTNFVG
KLDVRDGAGL YISSTSHLLA LQVSLTTLLH SITNNGVVSF DSRISRTSSS YDLQGVSFTN
NGEMYFAASG EFSSSTALTS ASWTNTRLLS FYRNQRTPGT VSLGMPLGSI TNNGQVCLNN
QVYEQTTQIK GLGCFTANGD STIYISNVLL AVSPKQNFYL TDKGSSMIVQ AVSTTQTFNV
YGFGEGNKIG LTIPLMGNLW NSAYAYDTTS GILTLRNLLL EQKFNIGTGY DPSKFQVVTD
SGSGIPSTIL GSVAYYGRVP ERTLPKSCQI PCKPIPEAPG TTPTQYTTTI TKTNTAGNTV
TESGVVNVST DKGGSWFTTT SMFPALSTAP STATVFSSDT IMSTVEPNTT ELASLTDIPI
ETSSVEELLS VMSNWEISSA PTLSIETPVS SHHSSMQHSS FESSADINTV FSSESAFETA
SDYIVSTPSS ISHSTMVPQS SVSALSVVSE SLASAEPSFV VPSESFIFSA SSAAPQPSSS
TYSVSFTTQF ETPSSAGPSL VTSVESNTEL ISSATQSSDI QTEFTSTWTT TNSDGSVVTE
SGIISQSGTS LTTLTTFQPA TSLVVPPYSV IETEFTSTWT TTNSDSSVAT ESGVVSQSDT
LLTTVTTFPP APSAIVPEFT SPWKINTSIE SSETLTVSAS SYETVGESLA AATSSYLSSA
TVVVAPSESE INTSSSILNN EEIASAPVSD TTSIAEHHDG SLSMTTTEFV NSNSLPSSHS
IVTATITSCN KSKCSESVVT YVSSVSCAII TVGDSEKNIS TVGNNVSSIV GDDVSNTQAI
TMATSTEGAT TLTSVSGAKP SVANDATNSV HTTDYTTATT GVQNGSSLSI PSDIPIEISV
ITPTNSSSSA ITIPYENGSN KESIENIKYL ALVVFGLMMF M
//
