ID C5ARM7_METEA Unreviewed; 383 AA.
AC C5ARM7;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=RND efflux transporter, membrane fusion protein subunit {ECO:0000313|EMBL:ACS42365.1};
GN OrderedLocusNames=MexAM1_META1p4737 {ECO:0000313|EMBL:ACS42365.1};
OS Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB
OS 9133 / AM1) (Methylobacterium extorquens).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylorubrum.
OX NCBI_TaxID=272630 {ECO:0000313|EMBL:ACS42365.1, ECO:0000313|Proteomes:UP000009081};
RN [1] {ECO:0000313|EMBL:ACS42365.1, ECO:0000313|Proteomes:UP000009081}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
RC {ECO:0000313|Proteomes:UP000009081};
RX PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA Lidstrom M.E.;
RT "Methylobacterium genome sequences: a reference blueprint to investigate
RT microbial metabolism of C1 compounds from natural and industrial sources.";
RL PLoS ONE 4:E5584-E5584(2009).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001510; ACS42365.1; -; Genomic_DNA.
DR RefSeq; WP_003600119.1; NC_012808.1.
DR AlphaFoldDB; C5ARM7; -.
DR STRING; 272630.MexAM1_META1p4737; -.
DR KEGG; mea:Mex_1p4737; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_1_0_5; -.
DR OrthoDB; 9813967at2; -.
DR Proteomes; UP000009081; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF15; HLYD FAMILY OF SECRETION PROTEINS; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009081};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..383
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002948145"
FT DOMAIN 58..271
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 318..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 383 AA; 40784 MW; DBB7395CBE048BB5 CRC64;
MRHALLVCAV VAGAAPLTAC QPSQEAPAPP PVRPVLTTLA QPTDSVIFGP FAGTVEPRYQ
SQLGFQIGGR VVARDVTVGD VVKKGQRLAA LDPIVSRFDL SRAEAELSDA KAQAENATAT
EARTRRLMEG GNVTQAQLDA AVARRDTAQA RLAQAGASLQ KARDQIGYTE LRADFDGVVT
QRLAEIGQVV SPGQGIVTLA RPETREAVVD IPETPAGAMP KDGLFTVVLQ SAPEITARGR
VREVAPFAEA GTRTRRVRLT LEEPGPAFRL GATITVALER RIERRFVLPA TALLDADGRR
SVWIVPAADK RGEENAAVQE ALQGDEPGDR HVERRDVTLD GDGPDGNGRI AVRTGLKPGE
RVVVAGAHSL RDGQTVRLAD DRN
//
