ID C5CDM2_KOSOT Unreviewed; 765 AA.
AC C5CDM2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Diguanylate cyclase and metal dependent phosphohydrolase {ECO:0000313|EMBL:ACR80034.1};
GN OrderedLocusNames=Kole_1340 {ECO:0000313|EMBL:ACR80034.1};
OS Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1).
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae;
OC Kosmotoga.
OX NCBI_TaxID=521045 {ECO:0000313|EMBL:ACR80034.1, ECO:0000313|Proteomes:UP000002382};
RN [1] {ECO:0000313|EMBL:ACR80034.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TBF 19.5.1 {ECO:0000313|EMBL:ACR80034.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C.,
RA Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G.,
RA Noll K.;
RT "Complete sequence of Thermotogales bacterium TBF 19.5.1.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACR80034.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TBF 19.5.1 {ECO:0000313|EMBL:ACR80034.1};
RX PubMed=21914881; DOI=10.1128/JB.05828-11;
RA Swithers K.S., Dipippo J.L., Bruce D.C., Detter C., Tapia R., Han S.,
RA Goodwin L.A., Han J., Woyke T., Pitluck S., Pennacchio L., Nolan M.,
RA Mikhailova N., Land M.L., Nesbo C.L., Gogarten J.P., Noll K.M.;
RT "Genome Sequence of Kosmotoga olearia Strain TBF 19.5.1, a Thermophilic
RT Bacterium with a Wide Growth Temperature Range, Isolated from the Troll B
RT Oil Platform in the North Sea.";
RL J. Bacteriol. 193:5566-5567(2011).
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DR EMBL; CP001634; ACR80034.1; -; Genomic_DNA.
DR RefSeq; WP_015868683.1; NC_012785.1.
DR AlphaFoldDB; C5CDM2; -.
DR STRING; 521045.Kole_1340; -.
DR KEGG; kol:Kole_1340; -.
DR eggNOG; COG0834; Bacteria.
DR eggNOG; COG2199; Bacteria.
DR eggNOG; COG2206; Bacteria.
DR HOGENOM; CLU_000445_92_5_0; -.
DR OrthoDB; 9804747at2; -.
DR Proteomes; UP000002382; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR037522; HD_GYP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR46663; DIGUANYLATE CYCLASE DGCT-RELATED; 1.
DR PANTHER; PTHR46663:SF2; GGDEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF13487; HD_5; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00062; PBPb; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS51832; HD_GYP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002382};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 255..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 305..375
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 385..438
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 467..601
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 556..765
FT /note="HD-GYP"
FT /evidence="ECO:0000259|PROSITE:PS51832"
FT COILED 281..315
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 765 AA; 87959 MW; 632DE10BBB050F84 CRC64;
MSRRIVLFLL IFLLGVTVIG RTIKVGIYEN KPLVFVENGV AKGVYIDILQ EIARKENWEL
SFVRGNWIEC LDKLRNGDID ILVAIAHTPE REAIYDFNKE AVFTNWGQIY CRKGFSPESV
IDLEGKMIAG VSGDIYYQHF YELLKNFNIS ADLVTVEEYH EVLSLLDLGE VDAGVISRLY
AQLNASNYRV KETGIIFSPV VLKFAFTKHK HRDLIITIDK YLKEFKEDPE SVYYESLDRW
LNIDVVESTF VIPQWLVVAL IVSSIFITIF AGTAFLLQKR VDLKTRELRE RNMELEELSK
KLKKSEEKFR QLIQSMDDVV FVLDVNKRFV EFYGEWFEKY GLDPEKLVGK KPSAVLDKIN
GESIEKAAEV ALESGSATVE WIVKRDDDNK DNKKDEGSKI YLGVSLSALR NGNGKVVGIV
GVARDITEKV KNNEKMRYLS FHDVLTGLYN RAFFEEELKR LDSHRQLPIS LIMIDINCLK
LTNDIFGHLE GDRVIKEVAQ ALRSSCRKED IIARWGGDEF VILLPKTPFE EVKEVGERIR
RTCRIKIVDD IELNVSQGIA TKEKFSQDMM DVLREAEMRM YEEKVALDVQ IKKALLRYFR
EKIAQGQGAV SSVECLEKMK EIAERFGYAV GLDNAEMNKL LLLVEYHDIG IVALKNHSEK
GLNYEKHPEV GYKIALNFPE IAPIAEYILY HHERWDGQGY PKKLRGNEIP LLSRLVSILD
FYAKEKCKDG EPKQSDERII LELGKRAGSE FDPDLVKLFT KLLLL
//
