ID C5DD36_LACTC Unreviewed; 721 AA.
AC C5DD36;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=DNA-binding protein RAP1 {ECO:0000256|RuleBase:RU367107};
GN OrderedLocusNames=KLTH0B07986g {ECO:0000313|EMBL:CAR21697.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21697.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR21697.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Involved in the regulation of telomere length, clustering and
CC has a specific role in telomere position effect (TPE).
CC {ECO:0000256|RuleBase:RU367107}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU367107}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367107}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU367107}.
CC -!- SIMILARITY: Belongs to the RAP1 family. {ECO:0000256|ARBA:ARBA00010467,
CC ECO:0000256|RuleBase:RU367107}.
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DR EMBL; CU928166; CAR21697.1; -; Genomic_DNA.
DR RefSeq; XP_002552135.1; XM_002552089.1.
DR AlphaFoldDB; C5DD36; -.
DR STRING; 559295.C5DD36; -.
DR GeneID; 8290975; -.
DR KEGG; lth:KLTH0B07986g; -.
DR eggNOG; ENOG502S85C; Eukaryota.
DR HOGENOM; CLU_014729_0_0_1; -.
DR InParanoid; C5DD36; -.
DR OMA; TENAWRD; -.
DR OrthoDB; 1406561at2759; -.
DR Proteomes; UP000002036; Chromosome B.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; IEA:UniProtKB-UniRule.
DR CDD; cd11655; rap1_myb-like; 2.
DR CDD; cd11653; rap1_RCT; 1.
DR Gene3D; 1.10.10.2170; -; 1.
DR Gene3D; 1.20.120.1480; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR021661; Rap1_C.
DR InterPro; IPR038104; Rap1_C_sf.
DR InterPro; IPR015280; Rap1_DNA-bd.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR039595; TE2IP/Rap1.
DR PANTHER; PTHR16466; TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR16466:SF6; TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF09197; Rap1-DNA-bind; 1.
DR Pfam; PF11626; Rap1_C; 1.
DR SMART; SM00292; BRCT; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367107};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU367107};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 52..132
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 249..309
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 249..305
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 721 AA; 80293 MW; B5CDA2A47E230F16 CRC64;
MSQQDDFETP STNAFEDALE HQSQHYEDGK PDTRSDKDAS GKDEGAGSGG DDQQDIFQDL
GFFIAHDESR QELEQLVSGH GGTVLSELPS GKSNKEFVVS TINASDLPTV TPTYIKTCCE
NNVLMKVQPF LVPYNEFRAV IDTQLQNESG EKPTAPADDA SETAEQPVES PSTKPGEDKR
PDADTPQPSE TNGGPMASVT AESNAGSEDQ GAGARRESVD SAKNSISGDE SDVVKTPVAP
SPPSARQPAA SHNKSSFTEE EDEFILDVVR KNPTRRTTHT LFDEISHYVP KHTGNSIRHR
YRVYLAKRLN FVYQVDSTGK LVRDDNGDLI KTTVLPKSLK NKFTASEDYA LSVEVKKQFY
RDIYQMDPDT GESLIKDINA PDGNLKGSFG AGSDERQNPG PSFKDFRVGE RRGPVPREFF
KKYADENPNH TENAWRDRFR KFLLTFGIDR YIEYYENEIA QSRVPQAMKN MTNRPKRPGV
PTPGNYNSFA KKVKTLSQQQ QQQAAAIIAA NGGAIDPAAL AFAIPEGDFL DEETLNFISG
LRRDLSKIES AGGAAFAYPQ EIAESIRNDF TNEEAQFDEI DPDKIPFPPA LVTNELFMPQ
FFHFGSTREF LDKINEVISR DYEPSQAEKL VQDLCDDVGV RKTFSTSILT ALSGDLMVFP
RYFLCMFHFG SNPPMNIPGI WTREDDEMLR SGEESNIKKL TQKHGAGRIE MRKRFIASDL
V
//
