ID C5DH99_LACTC Unreviewed; 3721 AA.
AC C5DH99;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=KLTH0E02530p {ECO:0000313|EMBL:CAR23160.1};
GN OrderedLocusNames=KLTH0E02530g {ECO:0000313|EMBL:CAR23160.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR23160.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR23160.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
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DR EMBL; CU928169; CAR23160.1; -; Genomic_DNA.
DR RefSeq; XP_002553597.1; XM_002553551.1.
DR STRING; 559295.C5DH99; -.
DR GeneID; 8291739; -.
DR KEGG; lth:KLTH0E02530g; -.
DR eggNOG; KOG0889; Eukaryota.
DR HOGENOM; CLU_000129_1_0_1; -.
DR InParanoid; C5DH99; -.
DR OMA; CLDLYGQ; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000002036; Chromosome E.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT DOMAIN 2594..3149
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3352..3709
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3689..3721
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 516..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 463..512
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 516..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3721 AA; 426539 MW; 8186D7992D6DEA77 CRC64;
MSYLERIEGL ASRLREDNDL AKSLSTISEI CEMVEPLGSS AEYEKFLNSI LPALMERLES
TLYTLDVMSP QQKLRNSILE VLNRCIMNEA FEPFAVKYLD KLLVVLQQDN EENGVLAMKI
ITGFFKSYKS ALQERVTDFI DVIMKIYKHM PELVRQTFND DLGDNGALDL TGLDNTSEVL
DPRGNGEAVQ SSDTLAATSK PLKRSMFSFK VLSECPITMV TLYSSYKQLT TSSLPQFMPL
VIELLTMEAD AQRKTREDFE AQGKRWISVS PNIKNRSAYC DFILSQIKAT SFLAYVFIRG
YAAEYLQNYV GFVPDLILRL LQDCPAELSA ARKELLHATR HILSTNYKKL FLSKINLLFD
EKVLIGNGFT SYETLRPLAY STVADFVHNV RGDLQLDDIE KTIKMYTGFL LDESLALTVQ
IMSAKLLLNL VERVLKLGKE NPNDSVRSKK LLIVIVDAYT TRFRNLNRQY DNLMKHHEEY
EKEKMKKSAT FRKELEKANE ETENFIREML RVKEPLKQET DAEGDVKMEE NVEGHTETSP
NDEESEPDNE DTTIDVFDIK FKSPILLSSP PNSDPLKDAF YLYRTLMSFL KTIIHDLKVF
NPPSTEYTTM NPKVWTSLSR IFSHEEVVVF KDLFHECILG LQFFSSPEGK TVTDKKHFDI
AAPSLPVSAT KDGRELMDYF AIMFMQIDSP TFNDIVEAEI DFLYQAMLRD SALLHVAQSF
LTSETTSPKF TGILLRFLKS KLSSLGNVDG NKSNILIRLF KLSFMSVNLF PITNEIVLLP
HLNDLILDSL KFSTTAEEPL VYLYLIRTLF RSIGGGRFEN LYRSIKPILQ VLLQSLNRMI
LTARRPHERD LYVELCLTVP VRLSVLAPYL SYLMKPLVFA LQGFPELTTQ GLRTLELCID
NLTAEYFDPI IEPVVEDVIR SLFKLLKPQP FNHQISHTAV RILGKLGGRN RRFLKPHSDL
RIAEELDIPV NATFRILGIN DEVPLSITPG VRSALDILQD YRGEAFYKKS AYNYLKSILQ
LFLKPSLAIP ENYEEWIGGA LKVLAQEVVK PPVSQDTEDE KIRDKRLLNS QEMLLAKILE
AVIFSASIEE LKSEANDLFQ NVVNHFCFLQ LNNALNKKMG ETEKFSLDVK LPKVSIDTNI
ILDAISEGLS SYMEESRNIS VSAVKQIFGT SERIYGSELS LKYSFIPLLV EKFIHQCYDE
AYFKKSSGVL GIQTMIEEVN IPVSFLKSYQ FDLIAGLLFV LIDTPLEAPG IIRERARKLI
ISILASTCKN ITEESLNEKG LQNTLIDIVC ELSNANEAVR SACQDALSTV SEVSGIPIVK
LMSHSKNFLL SPIFAKPLRA LPFPMQIGNV DAIIYCLSLQ GSFLEFNEEL YRLLHEAIAL
VDAEDESLAS AQRVTEYQTA EQLVQLRVVC IKLLSLALKN EEFASAQQGA TRIRILAVFF
KTMLKTSPKI IEATYQGLKS VLAENSKLPK ELLQNGLKPM LMNLSDHQKL TVSGLEALAK
LLELLIAYFK VEIGKKLLDH LDAWCRVEVL DMLFGKDLKE QTPTKIIYGI INIFHLLPPQ
ADIFLNDLLL KVMLVEKKLR LQLDSPFREP MAKYLNRFHS SVTSYFKNNL GSRDLVLLMC
SIIQRPEANN LRQDFEQELN NFYDYYMTGI SSNKVRVVSF FANVVEIFYS LERVKGDAWL
VNNGSFLYKL RSMLKLTLDI VEENDFHFDF LQLSQATGKV QDLHTRYLEL NGNNPAKLFE
FLEFAFTSGL KPSQSILSFI EKSVITTSEV ETKKLYLHHA LLFATSDKPF PATVFVLKNI
VNSTLVYEGL THKSLNRLIK EDDGTQPPWL GLLCSKIWKG SSTILDSFAA GEYDTFRFEL
LQLSSVFTEY AADLDPAIRK DIIRFCWNFI KLEDALVKQG AYMVTAYFIA KFEFPVKIVT
QVFVALLRTS QIESRYMVKR SLDLLAPVMH ERMASADPPN AWINWVRRVL SENNASQNST
LYQLLINHPD EFFESRELFI ASVINFVGKL TLMTNPNLEN QTLVIDLAEL ILKWEKKAKE
SDGGDDSVDG NETKEIKQQE TFGQREAFVT YLVRYVCVSN HRTSETELGF RTLKVLSEIL
SENYWPDVTV KLNFFEKFLV QHDLSSSNVS FYCVNALDVL DVILRNKSAS WIVSNLVLIQ
SLLDKCLRSD HHDIQEALQK VLGKVLSAIK HTEESSLESD TETPSKLLLN TLISIITEDL
QGTSSVAAGV MLTWTLFMHF PQYVDSLLPS IMKTFSKLCK DHLATSQPKD PATLEESRIT
TKLLEKVLYL LSMKVALLGD ARRPFLSTVA LLIDRSMDQN FLKKVIMIAR TWVFTNEIFP
TVKEKAAILT KMLAFEVRGE PKLSRQFYEI ILELFENKDF NNSEITVRME QPFLVGTRVD
DIYIRKRLMA ILDESLERDI KERLYYVIRD QNWEFIADYP WLNQALQLLY GAFDKDFSLD
LRGAYQLDQL GTALAEITIE KSDTEHEESP LHGLLERHKE FASNFSQVTC NDLVGPLIDI
FYRSPQAIHA AWINVFGAAY QSIPKNEKFG FVRSLVTLLS KDYHARQLNV RSNVVSTLLD
SISETDSLEL PPHLIKYLAT SYNSWYQSIK ILESLEESAS LENAKIIETN EDALLELYVN
LQEEDMFYGL WRRRAKYTET NIALSFEQIG LWDKAQQLYE AAQVKARSGA LPYSESEYSA
WEDNWIMCAE KLQHWDVLTE LAKHEGFTDL LLECGWRVAD WSADREALEQ SVKSVMDVPT
PRRQIFETFL ALQNFAETKK GDQEVKRLCD EGIQLSLHAW ASMPERFTPA HKFLLHSFQQ
YMEFLEATQV YANLASTSIQ NLDTKAQEVK RVLQAWRDRL PNIWDDINMW NDLITWRQHA
FQVINNAYLP LVPALQQASN NSNVNTHAYR GYHEIAWVIN RFAHVARKHN MPDVCISQLA
RIYTLPNIEI QEAFLKLREQ AKCHYQNMNE LTTGLDVISN TNLVYFGTVQ KAEFFTLKGM
FLSKLRAHDE ANQAFATAVQ IDLNLAKAWA QWGFFNDRRL SEEPQNISFA NNAISCYLQA
AGLYNNSKTR KLLCRILWLI GIEDSTGTLA GAFESFRGEI PVWYWITFIP QLLTSLSHKE
ANMVRQILIR IAKSYPQALH FQLRTTKEDF SVIQRQTMVA MGNSRLPNNK SPATASGTRQ
PWEYLDELNG ILKTAYPLLA LSLESLVDQI NQKFKTTSDE DLFRLINVLL IDATYNYNRL
PFPRENPLLP ASTETNLVRF SENLLPPHIS VKFNADFIDS KPNFEEYIKR LRYWRNRLEN
KLDRAPKIEN MEKWCPHLSN FHHQKFEDIE IPGQYLLNKD SNAHFVKISR FLPHVEFVRG
THSSYRRLTI RGHDGSLHSF AVQYPAVRHS RREERMFQLF RLFNETLSKN VQTRRRNVQF
TLPISVPLSP QVRIMNDSSS NTTMHNLYDE YCDKKGIDRG AIQDFVCQQL DAAYDKVLPP
PEITAVKVEI FSSIQSMFLP SSVMKNYFTG LFTQFEDFWL FRKQFSSQYA MFIFMTYMLA
INNRAPHKIS IDQVSGNVFT LEMLPARYPY ERVKQTAKNF EADIPPDSPV FHNNEAVPFR
LTPNIQKLIG ESALEGILSV NIFLVARALL EPDHELNTYL SLFIRDEVIS WYSNLHRSIV
EDPQLREIVR TNVDLITRKT AQLGHLSSKP SVVTQYVLEA ISAAVSPRNL AKMDQSFMPY
F
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