ID C5DJI6_LACTC Unreviewed; 320 AA.
AC C5DJI6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Protein BIG1 {ECO:0000256|ARBA:ARBA00022089};
GN OrderedLocusNames=KLTH0F16720g {ECO:0000313|EMBL:CAR24475.1};
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR24475.1, ECO:0000313|Proteomes:UP000002036};
RN [1] {ECO:0000313|EMBL:CAR24475.1, ECO:0000313|Proteomes:UP000002036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC {ECO:0000313|Proteomes:UP000002036};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}.
CC -!- SIMILARITY: Belongs to the BIG1 family.
CC {ECO:0000256|ARBA:ARBA00008203}.
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DR EMBL; CU928170; CAR24475.1; -; Genomic_DNA.
DR RefSeq; XP_002554912.1; XM_002554866.1.
DR AlphaFoldDB; C5DJI6; -.
DR STRING; 559295.C5DJI6; -.
DR GeneID; 8293145; -.
DR KEGG; lth:KLTH0F16720g; -.
DR eggNOG; ENOG502RXHV; Eukaryota.
DR HOGENOM; CLU_067894_0_0_1; -.
DR InParanoid; C5DJI6; -.
DR OMA; PNWNPIR; -.
DR OrthoDB; 1977668at2759; -.
DR Proteomes; UP000002036; Chromosome F.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR037654; Big1.
DR PANTHER; PTHR28285; PROTEIN BIG1; 1.
DR PANTHER; PTHR28285:SF2; PROTEIN BIG1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..320
FT /note="Protein BIG1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002948773"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 245..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 320 AA; 36306 MW; C56BFBD90E02329E CRC64;
MNALWCLAFL TGLVKCLDAI KDTVPAILCS YKLSPGMMQF QVELNGSSAL SKSEFLGIAK
TMISRRHSDA YVLVDIPGLA ASDFSVYEEE MEGIRYFVQS SSTALGFSEV NLVDTQTDVF
EELANFTKEE WDVDIQTVIR GEVESDFVPY IDSNPRIIRI NFKPLPEENT STPNSSRSRQ
DVIEAYDDFL KKVLRQLPSP EQTIILTSSQ KPSSQVIDGS EFYDILPDLF QDPQKLAEVE
INDKNLHNKP QFNEPKPRHS PPSEERLSIL EPQFLEENRG LVVLIIISIA LFFVLQTIQL
WRGKPKQPDK TKITTEKKLQ
//
