ID C5DR76_ZYGRC Unreviewed; 957 AA.
AC C5DR76;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=ZYRO0B06160p {ECO:0000313|EMBL:CAR26287.1};
GN OrderedLocusNames=ZYRO0B06160g {ECO:0000313|EMBL:CAR26287.1};
OS Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS / NRRL Y-229) (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=559307 {ECO:0000313|EMBL:CAR26287.1, ECO:0000313|Proteomes:UP000008536};
RN [1] {ECO:0000313|Proteomes:UP000008536}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC Y-229 {ECO:0000313|Proteomes:UP000008536};
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU928174; CAR26287.1; -; Genomic_DNA.
DR RefSeq; XP_002495220.1; XM_002495175.1.
DR AlphaFoldDB; C5DR76; -.
DR STRING; 559307.C5DR76; -.
DR GeneID; 8202367; -.
DR KEGG; zro:ZYRO0B06160g; -.
DR HOGENOM; CLU_002472_10_0_1; -.
DR InParanoid; C5DR76; -.
DR Proteomes; UP000008536; Chromosome B.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008536}.
FT DOMAIN 758..774
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 485..512
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 957 AA; 106837 MW; A66E8299D4E1787C CRC64;
MSSAARPELK FSDISEERRF YKRYLGLPEK PSTTLRAIDK GEYYTIIGHD AIFVADSIYH
TQSVLKDCKV EPSVARQTNE PLKYVTVLPQ VFSTLLKTCL LDLGYKVEIY DKACSLSKSA
SPGNIEQIQD LMNLAVDSSI VIAGLKLQFN TQEGHCVIGV AFIDTSNYKV GMLDIIDNEV
YSNLESFLIQ LGVRECLLPD MSKSESISSE LKKIIGVIER CGCVSTLIKS SDFTDKDVEL
DLANLVGDEL SLSLPRYSKS ALSSCGALLN YLQLLNEQDQ VGKYELIQHS LQEFMKLDAS
AIKALNLFPQ TANQPFGPAA GISLGGAGTK VSSLFQLLNH CRTNAGVRLL NEWLKQPLTD
VEQIEKRHIL VDYLIDQLEL RQILQTDHLP SVLDVRRITK KLNRNGNLED VLKIYQFGKK
IPEIADLLSS FLDDDQGSAE AKSLVKSTWL EPLMSHTEPL TKLLEMVETT VDLDAYEQHN
GFMIKVELNE GLANIRDQLD ALKDEINSIH LETAEDLGFD PEKKLKLENH HIHGWCMRLT
RNDARELRNH KEYLELSTVK AGIYFSTKKL KEIASETAVL QKEYDKQQSA LVKEIVSITL
TYSPVLEKLS LVLANLDVLC SFAHASSYAP IPYIRPKMHG LETTRTTRLV ASRHPVLEVQ
DDVTFIANDV NLESGVNDFL IITGPNMGGK STYIRQVGVI SLMAQIGCFV PCEEADIAVV
DAVLCRVGAG DSQLKGVSTF MVEMLETASI LKNATKNSLI IVDELGRGTS TYDGFGLAWA
IAEHIASKIG CFALFATHFH ELTALADKLP NVKNMQVVAH LEKDQDGQNE SDDITLLYKV
EPGISDQSFG IYVAEVVQFP QKIVKMAKRK ANELEELKSH DQDSKRAKLS VEELNEGNQR
LKTLLKDWVN QLRQQGLDDP RKLTEEDSQI QIQNLLKSLA GESSEDKFLQ YISDTLV
//
