ID C5FEJ2_ARTOC Unreviewed; 549 AA.
AC C5FEJ2;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN ORFNames=MCYG_01114 {ECO:0000313|EMBL:EEQ28226.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ28226.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS995701; EEQ28226.1; -; Genomic_DNA.
DR RefSeq; XP_002851010.1; XM_002850964.1.
DR AlphaFoldDB; C5FEJ2; -.
DR STRING; 554155.C5FEJ2; -.
DR GeneID; 9228471; -.
DR VEuPathDB; FungiDB:MCYG_01114; -.
DR eggNOG; KOG2449; Eukaryota.
DR HOGENOM; CLU_005391_1_10_1; -.
DR OMA; GGAKNHI; -.
DR OrthoDB; 275238at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF3; METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002035}.
FT DOMAIN 63..527
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 23..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 58776 MW; F642E02823E74086 CRC64;
MASSRNTSAT AIRRLHAMAQ QLKPAAAATS TTSAASTATS FPQSHERIAS PIDTANFIDN
EFTASRAETW IDLFDPATNN LVTRVPQSTE EEMKAAVASA QAAFPAWKAT SIMARQQIMF
KFVNLIRANW DRLAASITLE QGKTFADAKG DVLRGLQVAE TACGITTQMT GEVLEVAKDM
ETRSYREPLG VVSAICPFNF PAMIPLWCIP IATMTGNTLV MKPSERDPGA AMILAELARE
AGFPKGVINI IHGSAKTVDF ILDAPEIKAI SFVGSNRAGE YIFTRGSANG KRVQANLGAK
NHCAVLPDAN KNHALNAIAG AAFGAAGQRC MALSTLVMVG ETKEWLPEIA ERARALKVDG
GFEEGADLGP VISPESKKRI EDIIATAEKE GATILLDGRG YKPEKYPNGN WVGPTIITGV
KPHMTCYKEE IFGPVLVCLE VDTLDEAIDL INANEYGNGA AVFTRSGPTA TKFQRQIEAG
QLGINVPIPV PLPMFSFTGN KKSIAGGGAN TFYGKPGLQF YTQQKTVTSL WRSEDAISNK
ASVVMPTQS
//
