ID C5FJ66_ARTOC Unreviewed; 638 AA.
AC C5FJ66;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Serine/threonine-protein kinase gad8 {ECO:0000313|EMBL:EEQ29396.1};
GN ORFNames=MCYG_02215 {ECO:0000313|EMBL:EEQ29396.1};
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155 {ECO:0000313|EMBL:EEQ29396.1, ECO:0000313|Proteomes:UP000002035};
RN [1] {ECO:0000313|Proteomes:UP000002035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480 {ECO:0000313|Proteomes:UP000002035};
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
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DR EMBL; DS995702; EEQ29396.1; -; Genomic_DNA.
DR RefSeq; XP_002849281.1; XM_002849235.1.
DR AlphaFoldDB; C5FJ66; -.
DR STRING; 554155.C5FJ66; -.
DR GeneID; 9223218; -.
DR VEuPathDB; FungiDB:MCYG_02215; -.
DR eggNOG; KOG0598; Eukaryota.
DR HOGENOM; CLU_000288_120_0_1; -.
DR OMA; YLVMEFE; -.
DR OrthoDB; 10768at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd11651; YPK1_N_like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR PANTHER; PTHR24351:SF243; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00433; Pkinase_C; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EEQ29396.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002035};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 295..552
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 553..624
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 14..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 328
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 638 AA; 70940 MW; 0D0829E2F9B0750B CRC64;
MSWNLTKKLK ETHLAPLANT FSRSSTGSSP KGDASTEDGA PLSKTPTASS STSSNGIAAS
DATTNSPTQS LKPGILIVTL HEGKGFSLSP HYEHVFNSHY QGSSGSYSAS MRPSSSHASH
IPNSFTHAMR PQSTSGGINA APTNHGRYSA KHLPYALLDF DKLQVFVDSV SGTPENPLWA
GDNTSFKFDV SRVTDLNVQV YIRNPAARPG SGRSDDIFLG ACKINPRFEE PRRFVEDPKA
SKKEREKAAA AFAQKEKQLG QLGSEWIDLQ FGTGSIKIGV SFVENRQRSL TMADFELLKV
VGRGSFGKVM QVMKRDTKRI YAMKTIRKAH IISRSEVEHT LAERSVLSQI SNPFIVPLKF
SFQSPEKLYL VLAFVNGGEL FHHLQREQRF DINRARFYTA ELLCALECLH GFKVIYRDLK
PENILLDYSG HIALCDFGLC KLGMKDEDRT NTFCGTPEYL APELLLGHGY TKTVDWWTLG
VLLYEMLTGL PPFYDEDTNE MYRKILHDPL TFPNQEVVPA AARDLLSRLL DRDPHRRLGA
GGAGEIKGHH FFANIDWRKL LQRKYEPSFR PNVADARDTA NFDIEFTSEV PVDSYEEGSG
LSRTMQKPFE GWSYNRPVAG LNDGGGSVRD PAFGSIPE
//
