ID   C5KCA4_PERM5            Unreviewed;      1123 AA.
AC   C5KCA4;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=Pmar_PMAR027633 {ECO:0000313|EMBL:EER17917.1};
OS   Perkinsus marinus (strain ATCC 50983 / TXsc).
OC   Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC   Perkinsus.
OX   NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN   [1] {ECO:0000313|EMBL:EER17917.1, ECO:0000313|Proteomes:UP000007800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA   El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG671975; EER17917.1; -; Genomic_DNA.
DR   RefSeq; XP_002786121.1; XM_002786075.1.
DR   AlphaFoldDB; C5KCA4; -.
DR   EnsemblProtists; EER17917; EER17917; Pmar_PMAR027633.
DR   GeneID; 9063178; -.
DR   InParanoid; C5KCA4; -.
DR   OrthoDB; 2967382at2759; -.
DR   Proteomes; UP000007800; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd00303; retropepsin_like; 1.
DR   CDD; cd00590; RRM_SF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR008042; Retrotrans_Pao.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR22955; RETROTRANSPOSON; 1.
DR   Pfam; PF05380; Peptidase_A17; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS50102; RRM; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN          358..433
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          726..962
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          46..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..331
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1123 AA;  124765 MW;  BCCA719FFF128434 CRC64;
     MVSPKASDPV LTDDNKKSST EQSPPVWAWQ LKKELDSLTE SIAGIKSQLE SNADHKTRHD
     ANGTTGATGD DSKDGPANTV HGIVEEVKQQ LDSTKSDRSA KSSLVIEPLV IMKISKQAKS
     AGVIEGGRFS GVTDKRGYMI FKKTIMNQPE IQFSGTGELS SAYQYFYIIN NVSTPLQQLI
     NEQCHVKGNT LFSQRVVTAW RVLRLYSDLG SEMELHRKWE NLKCDGPTTL EVYIAAIQTM
     KDQIGEVREC PLTDSELRAR LYSGLPTEAR LYLDRMPLTS VSTMESMISE TRRWAQLRVR
     YGASLVGTPT TATSNPTIST TRGASSAKVK SATPSKKDKK KTDKEANVIE FSTSPDAKRV
     FLSGVPLAWN YQDVKDFVSR LLGHDTDVYV RLLPRRGFVT VKFNDHKPAQ AFIEASNGAD
     IGGKRIRARF DKFESQDATI NPTTTAAPTT EGNAVQVPYD EVFFQGGSQP CEEEEGESPD
     CLIAEFHDGS CEQPVPTATV SDSFQDHSAC MVSMVECNEG SSDVQVLEKA SNGLPLIPVW
     FEGDEHRYYA LLDSGATDVF ITRRVFNSMK ESIPELSTTT TATSSMLTMI NGTSCAIVDK
     VIGVKIHLAS HQVRQCDCYV IEHSKYDVIV PKSLLGPCTW VVSAESHCPD RIIFRPMGIF
     DDDSCIPDRW LQDNSLAIQC NHAEVVADRL SVSIPWKSSA RPRYNFKDVW ARDRKVLTRL
     KHDPVKYEAY LSAVHELLES GVVVEKPPDQ SPHDFAKFYT AVVPVFNLNR TSTKCRLCLD
     ARPLNTYTTT TGDGTGSTSM DLFGTLMLWR SFERASCDDL SKAFWQVLVR GGKVDDEDTD
     YLALVVAGHL VKFSRVPFGT NWSPWALGSS LEKIFSSLPA KIRDGVGYYV DDVLIGASSI
     SEVEASRISV VQALKRRGFD INEKKRFHNL GTARSSIGHD VTVSDVTGMD GLQMASWLGY
     RWFISPNCDN VDIKLPDFRL PREVRMSSLR SITARLFDPL GLVAEASLEI KALLRQLHNA
     GFGEVHHGLV KNDAITGDYL LRSQECLQQC EKYFTCSTRM LPPRYIPIEG LVVFVDASEF
     AMAVDVRSRA NGRRLLSRIS THPGGSIPRR ELESLRMGVV RIR
//